Theoretical aspects of applying sib-pair linkage tests to livestock species

The Haseman-Elston (HE) sib-pair linkage test in its original form is computationally simple but suffers from low power. With the advent of highly polymorphic markers, the exclusive use of fully informative matings (ie matings where the number of genes identical by descent for any sib pair can be in...

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Bibliographic Details
Published in:Genetics selection evolution (Paris) 1992-03, Vol.24 (1), p.29-42, Article 29
Main Authors: GÖTZ, K, OLLIVIER, L
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Classical genetics, quantitative genetics, hybrids
Fundamental and applied biological sciences. Psychology
Genetics
Genetics of eukaryotes. Biological and molecular evolution
Life Sciences
Livestock
Vertebrata
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Summary:The Haseman-Elston (HE) sib-pair linkage test in its original form is computationally simple but suffers from low power. With the advent of highly polymorphic markers, the exclusive use of fully informative matings (ie matings where the number of genes identical by descent for any sib pair can be inferred without error) for the HE test becomes feasible. This article examines the influence of highly polymorphic marker systems (5 alleles), large family sizes (6 full-sibs) and hierarchical breeding structures (mating ratio of 25) on the power of the HE test by means of simulation studies. Simulations are performed under the assumption that the costs of marker genotyping are a limiting factor for marker-QTL linkage studies. Consequently, the total number of individuals (parents and offspring) typed is fixed at 5,000 in each of the situations compared.
ISSN:0999-193X
1297-9686
1297-9686
DOI:10.1186/1297-9686-24-1-29