Identification of Relaxin-Responsive Cells in the Human Choriodecidua at Term

The decidua of the human maternal–fetal interface is a local source of intrauterine relaxin, and the choriodecidua expresses its receptor (LGR7). Since these tissues consist of a variety of cells, we sought to identify the primary cell(s) responsible for LGR7 expression and relaxin responsiveness.

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2009-04, Vol.1160 (1), p.136-137
Main Authors: Horton, Jaime S., Yamamoto, Sandra Y., Bryant-Greenwood, Gillian D.
Format: Article
Language:English
Subjects:
cAMP
Cell Line
Cells, Cultured
chorion
Cyclic AMP - metabolism
decidua
Decidua - cytology
Decidua - drug effects
Dose-Response Relationship, Drug
Enzyme-Linked Immunosorbent Assay
Female
Humans
In Vitro Techniques
LGR7
Macrophages - drug effects
Macrophages - metabolism
Matrix Metalloproteinases - metabolism
Polymerase Chain Reaction
Pregnancy
Pregnancy Outcome
primary cells
Receptors, G-Protein-Coupled - genetics
Receptors, Peptide - genetics
relaxin
Relaxin - pharmacology
Stromal Cells - drug effects
Stromal Cells - metabolism
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Description
Summary:The decidua of the human maternal–fetal interface is a local source of intrauterine relaxin, and the choriodecidua expresses its receptor (LGR7). Since these tissues consist of a variety of cells, we sought to identify the primary cell(s) responsible for LGR7 expression and relaxin responsiveness.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.2008.03786.x