Early diagnosis of oesophageal cancer

Squamous cell carcinoma and adenocarcinoma of the oesophagus are cancers that develop from distinct epithelial sub-types; however, they are both related to chronic inflammation of differing aetiologies. Inflammation leads to somatically inherited genetic mutations altering control of the cell cycle,...

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Bibliographic Details
Published in:British journal of cancer 2009-07, Vol.101 (1), p.1-6
Main Authors: Bird-Lieberman, E L, Fitzgerald, R C
Format: Article
Language:English
Subjects:
Ablation
Apoptosis
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Cancer Research
Cancer therapies
Cell cycle
Drug Resistance
Early Detection of Cancer
Endoscopy
Epidemiology
Esophageal cancer
Esophageal Neoplasms - diagnosis
Esophageal Neoplasms - pathology
Esophagus
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Inflammation
Lymphatic system
Medical prognosis
Medical research
Medical sciences
Metastasis
mini-review
Minireview
Molecular Medicine
Mutation
Neoplasm Staging
Oncology
Pathogenesis
Tumors
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Description
Summary:Squamous cell carcinoma and adenocarcinoma of the oesophagus are cancers that develop from distinct epithelial sub-types; however, they are both related to chronic inflammation of differing aetiologies. Inflammation leads to somatically inherited genetic mutations altering control of the cell cycle, DNA replication and apoptosis, which together result in autonomous and uncontrolled proliferation. These cancers have often metastasised to lymph nodes and distant organs before symptomatic presentation and therefore carry a poor prognosis. It is therefore vital to diagnose oesophageal cancer at an early stage, before the development of symptoms, when treatment can dramatically improve prognosis. Understanding the pathogenesis of these cancers is vital to guide early diagnostic strategies.
ISSN:0007-0920
1532-1827
DOI:10.1038/sj.bjc.6605126