Atrophy of basal ganglia nuclei and negative symptoms in temporal lobe epilepsy

Recent work has identified the presence of negative symptoms in a subset of temporal lobe epilepsy (TLE) patients. The authors hypothesized that negative symptoms in TLE are associated with disruption in the mesolimbic system. Basal ganglia and anterior cingulate region of interest volumes were comp...

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Bibliographic Details
Published in:The journal of neuropsychiatry and clinical neurosciences 2009, Vol.21 (2), p.152-159
Main Authors: Geary, Elizabeth K, Seidenberg, Michael, Hermann, Bruce
Format: Article
Language:English
Subjects:
Adult
Affective Symptoms - pathology
Affective Symptoms - psychology
Atrophy
Basal Ganglia - pathology
Epilepsy, Temporal Lobe - pathology
Epilepsy, Temporal Lobe - psychology
Female
Humans
Magnetic Resonance Imaging - methods
Male
Middle Aged
Young Adult
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Summary:Recent work has identified the presence of negative symptoms in a subset of temporal lobe epilepsy (TLE) patients. The authors hypothesized that negative symptoms in TLE are associated with disruption in the mesolimbic system. Basal ganglia and anterior cingulate region of interest volumes were compared between 22 TLE patients with negative symptoms, 22 TLE patients without negative symptoms, and 22 comparison subjects. The negative symptom group showed significantly reduced volumes in the putamen and globus pallidus. It appears that these structures within the broader mesolimbic system contribute to the phenomenon of negative symptoms in TLE.
ISSN:0895-0172
1545-7222
DOI:10.1176/appi.neuropsych.21.2.152