Solitary Fibrous Tumor of the Oral Cavity: Clinicopathologic and Immunohistochemical Study of 21 Cases

We describe clinical, morphologic, and immunohistochemical features of 21 cases of solitary fibrous tumor presenting in the oral cavity. There were 9 male and 12 female patients with a median age of 51 years (range 37–83). The most common locations included the buccal mucosa (the most common site),...

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Bibliographic Details
Published in:Head & neck pathology (Totowa, N.J.) N.J.), 2009-06, Vol.3 (2), p.106-115
Main Authors: O’Regan, Esther M., Vanguri, Vijay, Allen, Carl M., Eversole, Lewis Roy, Wright, John M., Woo, Sook-Bin
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antigens, CD34 - biosynthesis
Biomarkers, Tumor - analysis
Dentistry
Female
Humans
Immunohistochemistry
Male
Medicine
Medicine & Public Health
Middle Aged
Mouth Neoplasms - metabolism
Mouth Neoplasms - pathology
Oral and Maxillofacial Surgery
Original Paper
Otorhinolaryngology
Pathology
Proto-Oncogene Proteins c-bcl-2 - biosynthesis
Solitary Fibrous Tumors - metabolism
Solitary Fibrous Tumors - pathology
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Summary:We describe clinical, morphologic, and immunohistochemical features of 21 cases of solitary fibrous tumor presenting in the oral cavity. There were 9 male and 12 female patients with a median age of 51 years (range 37–83). The most common locations included the buccal mucosa (the most common site), lip, maxillary or mandibular vestibule and tongue. Histopathologic examination showed well-circumscribed tumors with two well-defined patterns: the classic pattern with densely cellular areas alternating with hypocellular areas in a variably collagenous, vascular stroma and a more uniformly sclerotic pattern with only subtle classic areas. The spindle-shaped neoplastic cells consistently showed immunoreactivity for antibodies directed against CD34. Five of nineteen cases (26%) were reactive for CD99 and 19 of 19 for Bcl-2. Follow-up information was available in 17 cases and averaged 54 months, with no evidence of recurrence or metastasis in any of these patients. Awareness that solitary fibrous tumor may present in the oral cavity is important so that confusion with other spindle cell neoplasms can be avoided. We also briefly describe the differential diagnosis and compare this series, the largest single series of intraoral SFT, to cases previously reported in the literature.
ISSN:1936-055X
1936-0568
DOI:10.1007/s12105-009-0111-8