Surface Mobility of Postsynaptic AMPARs Tunes Synaptic Transmission

AMPA glutamate receptors (AMPARs) mediate fast excitatory synaptic transmission. Upon fast consecutive synaptic stimulation, transmission can be depressed. Recuperation from fast synaptic depression has been attributed solely to recovery of transmitter release and/or AMPAR desensitization. We show t...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2008-04, Vol.320 (5873), p.201-205
Main Authors: Heine, Martin, Groc, Laurent, Frischknecht, Renato, Béïque, Jean-Claude, Lounis, Brahim, Rumbaugh, Gavin, Huganir, Richard L, Cognet, Laurent, Choquet, Daniel
Format: Article
Language:English
Subjects:
Action Potentials
Aminoacid receptors (glycine, glutamate, gaba)
Animals
Antibodies
Biological and medical sciences
Brain
Brain research
Calcium
Calcium - metabolism
Cell receptors
Cell structures and functions
Cells, Cultured
Diffusion
Excitatory Amino Acid Antagonists - pharmacology
Excitatory Postsynaptic Potentials
Fluorescence
Fluorescence Recovery After Photobleaching
Fundamental and applied biological sciences. Psychology
Glutamic Acid - metabolism
Hippocampus - cytology
Hippocampus - physiology
Inurement
Kynurenic Acid - pharmacology
Molecular and cellular biology
Neuronal Plasticity
Neurons
Neurons - physiology
Neuroscience
Neurosciences
Patch-Clamp Techniques
Physiological regulation
Rats
Rats, Sprague-Dawley
Receptors
Receptors, AMPA - metabolism
Recombinant Fusion Proteins - metabolism
Synapses
Synapses - drug effects
Synapses - physiology
Synaptic transmission
Synaptic Transmission - drug effects
Transfection
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Description
Summary:AMPA glutamate receptors (AMPARs) mediate fast excitatory synaptic transmission. Upon fast consecutive synaptic stimulation, transmission can be depressed. Recuperation from fast synaptic depression has been attributed solely to recovery of transmitter release and/or AMPAR desensitization. We show that AMPAR lateral diffusion, observed in both intact hippocampi and cultured neurons, allows fast exchange of desensitized receptors with naïve functional ones within or near the postsynaptic density. Recovery from depression in the tens of millisecond time range can be explained in part by this fast receptor exchange. Preventing AMPAR surface movements through cross-linking, endogenous clustering, or calcium rise all slow recovery from depression. Physiological regulation of postsynaptic receptor mobility affects the fidelity of synaptic transmission by shaping the frequency dependence of synaptic responses.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1152089