Serum levels of homocysteine in mice with malignant tumours

Oxygen radicals and malondialdehyde (MDA) are tumourigenic. Homocysteine generates oxygen radicals. The possibility exists that hyperhomocysteinemia is a risk factor for cancer. To investigate if serum levels of homocysteine and MDA are elevated in mice with malignant tumours. Levels of serum homocy...

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Bibliographic Details
Published in:Experimental and clinical cardiology 2003, Vol.8 (3), p.147-149
Main Authors: Qureshi, Mabood, Zhang, Xueshu, Ul-Haq, Inam, Xiang, Jim, Prasad, Kailash
Format: Article
Language:English
Subjects:
Experimental Cardiology
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Summary:Oxygen radicals and malondialdehyde (MDA) are tumourigenic. Homocysteine generates oxygen radicals. The possibility exists that hyperhomocysteinemia is a risk factor for cancer. To investigate if serum levels of homocysteine and MDA are elevated in mice with malignant tumours. Levels of serum homocysteine and MDA were estimated in 22 control and 22 tumour-bearing Balb/c mice. Serum homocysteine levels in control and tumour-bearing mice were 3.01+/-0.26 mumol/L and 4.05+/-0.46 mumol/L, respectively. The serum levels of MDA were 6.23+/-0.72 nmol/mL and 11.60+/-1.72 nmol/mL, respectively, in control and tumour-bearing mice. These results suggest that cancer in mice is associated with an increase in serum levels of homocysteine and the lipid peroxidation product MDA. It is, however, not known if this rise in homocysteine and MDA is due to cancer or if this rise causes cancer.
ISSN:1205-6626