Pleiotropic effects of bombesin and neurotensin on intestinal mucosa： Not just trefoil peptides

Bombesin and neurotensin are neuropeptides which exert a wide spectrum of biological actions on gastrointestinal tissues influencing intestinal growth and adaptation, intestinal motility, blood flow, secretion, nutrient absorption and immune response. Based mainly on their well-established potent en...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2008-06, Vol.14 (22), p.3602-3603
Main Authors: Assimakopoulos, Stelios-F, Scopa, Chrisoula-D, Nikolopoulou, Vassiliki-N, Vagianos, Constantine-E
Format: Article
Language:English
Subjects:
Animals
Apoptosis - drug effects
Bombesin - pharmacology
Bombesin - therapeutic use
Cell Proliferation - drug effects
Colitis - chemically induced
Colitis - drug therapy
Colitis - pathology
Disease Models, Animal
Intestinal Mucosa - drug effects
Intestinal Mucosa - pathology
Letters To The Editor
Neurotensin - pharmacology
Neurotensin - therapeutic use
Neurotransmitter Agents - pharmacology
Neurotransmitter Agents - therapeutic use
Oxidative Stress - drug effects
Rats
Trinitrobenzenesulfonic Acid
多效性
神经肽
肠黏膜
调整肽
铃蟾肽
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Summary:Bombesin and neurotensin are neuropeptides which exert a wide spectrum of biological actions on gastrointestinal tissues influencing intestinal growth and adaptation, intestinal motility, blood flow, secretion, nutrient absorption and immune response. Based mainly on their well-established potent enterotrophic effect, numerous experimental studies investigated their potential positive effect on the atrophic or injured intestinal mucosa. These peptides proved to be effective mucosa-healing factors, but the potential molecular and cellular mechanisms for this action remained unresolved. In a recently published study （World J Gastroenterol 2008; 14（8）： 1222-1230）, it was shown that their protective effect on the intestine in experimentally induced inflammatory bowel disease was related to anti-inflammatory, antioxidant and antiapoptotic actions. These results are in close agreement with our previous studies on jaundiced and hepatectomized rats that showed a regulatory effect of bombesin and neurotensin on critical cellular processes such as enterocyte＇ proliferation and death, oxidative stress and redox equilibrium, tight junctions＇ formation and function, and inflammatory response. The pleiotropic effects of bombesin and neurotensin on diverse types of intestinal injury may justify their consideration for clinical trials.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.14.3602