Correlated Diffusion of Membrane Proteins and Their Effect on Membrane Viscosity

We extend the Saffman theory of membrane hydrodynamics to account for the correlated motion of membrane proteins, along with the effect of protein concentration on that correlation and on the response of the membrane to stresses. Expressions for the coupling diffusion coefficients of protein pairs a...

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Bibliographic Details
Published in:Biophysical journal 2009-04, Vol.96 (8), p.3041-3049
Main Authors: Oppenheimer, Naomi, Diamant, Haim
Format: Article
Language:English
Subjects:
Algorithms
Biochemistry
Biophysical Theory and Modeling
Cell Membrane - chemistry
Cell Membrane - metabolism
Correlation analysis
Diffusion
Gene expression
Membrane Fluidity
Membrane Proteins - metabolism
Membranes
Models, Biological
Proteins
Viscosity
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Summary:We extend the Saffman theory of membrane hydrodynamics to account for the correlated motion of membrane proteins, along with the effect of protein concentration on that correlation and on the response of the membrane to stresses. Expressions for the coupling diffusion coefficients of protein pairs and their concentration dependence are derived in the limit of small protein size relative to the interprotein separation. The additional role of membrane viscosity as determining the characteristic length scale for membrane response leads to unusual concentration effects at large separation—the transverse coupling increases with protein concentration, whereas the longitudinal one becomes concentration-independent.
ISSN:0006-3495
1542-0086
DOI:10.1016/j.bpj.2009.01.020