Evaluation of lenticular antioxidant and redox system components in the lenses of acetyl-L-carnitine treatment in BSO-induced glutathione deprivation

To investigate whether acetyl-L-carnitine (ALCAR) retards L-buthionine-(S,R)-sulfoximine (BSO)-induced cataractogenesis in Wistar rat pups. On postpartum day 3, group I pups received intraperitoneal (ip) saline and group II and group III pups received i.p. injections of BSO once daily for three cons...

Full description

Saved in:
Bibliographic Details
Published in:Molecular vision 2009-07, Vol.15, p.1485-1491
Main Authors: Elanchezhian, R, Sakthivel, M, Isai, M, Geraldine, P, Thomas, P A
Format: Article
Language:English
Subjects:
Acetylcarnitine - pharmacology
Animals
Antioxidants - metabolism
Buthionine Sulfoximine - toxicity
Glutathione - deficiency
Lens, Crystalline - drug effects
Lens, Crystalline - enzymology
Lens, Crystalline - metabolism
Lens, Crystalline - pathology
Malondialdehyde - metabolism
Oxidation-Reduction - drug effects
Rats
Rats, Wistar
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To investigate whether acetyl-L-carnitine (ALCAR) retards L-buthionine-(S,R)-sulfoximine (BSO)-induced cataractogenesis in Wistar rat pups. On postpartum day 3, group I pups received intraperitoneal (ip) saline and group II and group III pups received i.p. injections of BSO once daily for three consecutive days. In addition, group III pups received ip ALCAR once daily from postpartum days 3-15. Both eyes of each pup were examined up from postpartum day 16 to day 30. After sacrifice, extricated pup lenses were analyzed for antioxidant and redox system components. There was dense lenticular opacification in all group II pups, minimal opacification in 40% of group III pups, and no opacification in 60% of group III pups and in all of group I pups. Group II lenses exhibited significantly lower values of antioxidant and redox system components and higher malondialdehyde concentrations than in group I or group III lenses. ALCAR prevents cataractogenesis in the BSO-induced cataract model, possibly by inhibiting depleting antioxidant enzyme and redox system components and inhibiting lipid peroxidation.
ISSN:1090-0535