Adipokines and ghrelin in gastric cancer cachexia

• Published in: World journal of gastroenterology : WJG 2008-06, Vol.14 (23), p.3633-3641
• Main Authors: Kerem, Mustafa, Ferahkose, Zafer, Yilmaz, Utku Tonguc, Pasaoglu, Hatice, Ofluoglu, Ebru, Bedirli, Abdulkadir, Salman, Bulent, Sahin, Tevfik Tolga, Akin, Murat
• Format: Article
• Language: English
• Subjects: Adipokines - blood; Adiponectin - blood; Adult; Aged; Blood Glucose - metabolism; Body Mass Index; C-Reactive Protein - metabolism; Cachexia - etiology; Cachexia - metabolism; Cachexia - pathology; Case-Control Studies; Female; Gastric Cancer; Ghrelin - blood; Humans; Insulin - blood; Insulin-Like Growth Factor I - metabolism; Leptin - blood; Male; Middle Aged; Multivariate Analysis; Neoplasm Staging; Prealbumin - metabolism; Prospective Studies; Resistin - blood; Serum Albumin - metabolism; Severity of Illness Index; Stomach Neoplasms - complications; Stomach Neoplasms - metabolism; Stomach Neoplasms - pathology; Time Factors; 恶病质; 抵抗素; 治疗方法
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.14.3633

AIM： To investigate the roles of the adipocytokines, ghrelin and leptin in gastric cancer cachexia. METHODS： Resistin, ghrelin, leptin, adiponectin, insulin and insulin-like growth factor （IGF-Ⅰ）, were measured in 30 healthy subjects, and 60 gastric cancer patients of which 30 suffered from cancerinduced cachexia and 30 served as a control group. The relationships between hormones, body mass index （BMI） loss ratio, age, gender, and Glasgow Prognostic Score （GPS） were investigated. RESULTS： Cachexia patients had higher tumor stage and GPS when compared with non-cachexia patients （P 〈 0.05）. Ghrelin, resistin, leptin, adiponectin and IGF- Ⅰ, showed a significant correlation with BMI loss ratio and GPS （P 〈 0.05）. A strong correlation was seen between GPS and BMI loss （R = -0.570, P 〈 0.0001）. Multivariate analysis indicated that BMI loss was significantly independent as a predictor of ghrelin, resistin, leptin and IGF-Ⅰ （P 〈 0.05）. Existence of an important significant relationship between resistin and insulin resistance was also noted. CONCLUSION： These results showed that serum ghrelin, leptin, adiponectin, and IGF-Ⅰ play important roles in cachexia-related gastric cancers. No relationship was found between resistin and cancer cachexia. Also, because of the correlation between these parameters and GPS, these parameters might be used as a predictor factor.