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Pessimism correlates with leukocyte telomere shortness and elevated interleukin-6 in post-menopausal women
Abstract The combination of less positive and more negative expectations for the future (i.e., lower optimism and higher pessimism) increases risk for disease and early mortality. We tested the possibility that expectancies might influence health outcomes by altering the rate of biological aging, sp...
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Published in: | Brain, behavior, and immunity behavior, and immunity, 2009-05, Vol.23 (4), p.446-449 |
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creator | O’Donovan, A Lin, J Dhabhar, F.S Wolkowitz, O Tillie, J.M Blackburn, E Epel, E |
description | Abstract The combination of less positive and more negative expectations for the future (i.e., lower optimism and higher pessimism) increases risk for disease and early mortality. We tested the possibility that expectancies might influence health outcomes by altering the rate of biological aging, specifically of the immune system (immunosenescence). However, no studies to date have examined associations between optimism or pessimism and indicators of immunosenescence such as leukocyte telomere length (TL) and interleukin-6 (IL-6) levels. We investigated whether dispositional tendencies towards optimism and pessimism were associated with TL and IL-6 in a sample of 36 healthy post-menopausal women. Multiple regression analyses where optimism and pessimism were entered simultaneously, and chronological age and caregiver status were controlled, indicated that pessimism was independently associated with shorter TL ( β = −.68, p = .001) and higher IL-6 concentrations ( β = .50, p = .02). In contrast, optimism was not independently associated with either measure of immunosenescence. These findings suggest that dispositional pessimism may increase IL-6 and accelerate rate of telomere shortening. Mechanistic causal relationships between these parameters need to be investigated. |
doi_str_mv | 10.1016/j.bbi.2008.11.006 |
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We tested the possibility that expectancies might influence health outcomes by altering the rate of biological aging, specifically of the immune system (immunosenescence). However, no studies to date have examined associations between optimism or pessimism and indicators of immunosenescence such as leukocyte telomere length (TL) and interleukin-6 (IL-6) levels. We investigated whether dispositional tendencies towards optimism and pessimism were associated with TL and IL-6 in a sample of 36 healthy post-menopausal women. Multiple regression analyses where optimism and pessimism were entered simultaneously, and chronological age and caregiver status were controlled, indicated that pessimism was independently associated with shorter TL ( β = −.68, p = .001) and higher IL-6 concentrations ( β = .50, p = .02). In contrast, optimism was not independently associated with either measure of immunosenescence. These findings suggest that dispositional pessimism may increase IL-6 and accelerate rate of telomere shortening. Mechanistic causal relationships between these parameters need to be investigated.</description><identifier>ISSN: 0889-1591</identifier><identifier>EISSN: 1090-2139</identifier><identifier>DOI: 10.1016/j.bbi.2008.11.006</identifier><identifier>PMID: 19111922</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Affect ; Aged ; Aged, 80 and over ; Aging ; Aging - blood ; Aging - genetics ; Aging - immunology ; Allergy and Immunology ; Attitude ; Caregivers ; Enzyme-Linked Immunosorbent Assay ; Female ; Health Behavior ; Humans ; Interleukin-6 ; Interleukin-6 - blood ; Leukocytes - immunology ; Leukocytes - metabolism ; Middle Aged ; Optimism ; Patient Selection ; Personality - genetics ; Personality Inventory ; Pessimism ; Psychiatry ; Regression Analysis ; Reverse Transcriptase Polymerase Chain Reaction ; Stress, Psychological - blood ; Stress, Psychological - genetics ; Stress, Psychological - immunology ; Surveys and Questionnaires ; Telomere - genetics ; Telomere length</subject><ispartof>Brain, behavior, and immunity, 2009-05, Vol.23 (4), p.446-449</ispartof><rights>Elsevier Inc.</rights><rights>2008 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c536t-a4572fd6b527abfdd3e1eb77be392a95e903b26c501959c2013380731ab5fae03</citedby><cites>FETCH-LOGICAL-c536t-a4572fd6b527abfdd3e1eb77be392a95e903b26c501959c2013380731ab5fae03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19111922$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>O’Donovan, A</creatorcontrib><creatorcontrib>Lin, J</creatorcontrib><creatorcontrib>Dhabhar, F.S</creatorcontrib><creatorcontrib>Wolkowitz, O</creatorcontrib><creatorcontrib>Tillie, J.M</creatorcontrib><creatorcontrib>Blackburn, E</creatorcontrib><creatorcontrib>Epel, E</creatorcontrib><title>Pessimism correlates with leukocyte telomere shortness and elevated interleukin-6 in post-menopausal women</title><title>Brain, behavior, and immunity</title><addtitle>Brain Behav Immun</addtitle><description>Abstract The combination of less positive and more negative expectations for the future (i.e., lower optimism and higher pessimism) increases risk for disease and early mortality. We tested the possibility that expectancies might influence health outcomes by altering the rate of biological aging, specifically of the immune system (immunosenescence). However, no studies to date have examined associations between optimism or pessimism and indicators of immunosenescence such as leukocyte telomere length (TL) and interleukin-6 (IL-6) levels. We investigated whether dispositional tendencies towards optimism and pessimism were associated with TL and IL-6 in a sample of 36 healthy post-menopausal women. Multiple regression analyses where optimism and pessimism were entered simultaneously, and chronological age and caregiver status were controlled, indicated that pessimism was independently associated with shorter TL ( β = −.68, p = .001) and higher IL-6 concentrations ( β = .50, p = .02). In contrast, optimism was not independently associated with either measure of immunosenescence. These findings suggest that dispositional pessimism may increase IL-6 and accelerate rate of telomere shortening. Mechanistic causal relationships between these parameters need to be investigated.</description><subject>Affect</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Aging - blood</subject><subject>Aging - genetics</subject><subject>Aging - immunology</subject><subject>Allergy and Immunology</subject><subject>Attitude</subject><subject>Caregivers</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Health Behavior</subject><subject>Humans</subject><subject>Interleukin-6</subject><subject>Interleukin-6 - blood</subject><subject>Leukocytes - immunology</subject><subject>Leukocytes - metabolism</subject><subject>Middle Aged</subject><subject>Optimism</subject><subject>Patient Selection</subject><subject>Personality - genetics</subject><subject>Personality Inventory</subject><subject>Pessimism</subject><subject>Psychiatry</subject><subject>Regression Analysis</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Stress, Psychological - blood</subject><subject>Stress, Psychological - genetics</subject><subject>Stress, Psychological - immunology</subject><subject>Surveys and Questionnaires</subject><subject>Telomere - genetics</subject><subject>Telomere length</subject><issn>0889-1591</issn><issn>1090-2139</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNp9kkuLFDEUhQtRnHb0B7iRWumqynuTrkcQBmTwBQMK6jqkUrft9KSSNkn10P_eFN34WswqhHznkHvOLYrnCDUCtq939TCYmgH0NWIN0D4oVggCKoZcPCxW0PeiwkbgRfEkxh0ANBz7x8UFCkQUjK2K3ReK0UwmTqX2IZBViWJ5Z9K2tDTfen1MVCayfqJAZdz6kFxWlMqNJVk6ZHwsjUsUFty4qs23cu9jqiZyfq_mqGx5l-XuafFoo2ykZ-fzsvj-_t2364_VzecPn67f3lS64W2q1Lrp2GZsh4Z1atiMIyekoesG4oIp0ZAAPrBWN4CiEZoBct5Dx1ENzUYR8Mvi6uS7n4eJRk0uBWXlPphJhaP0ysh_X5zZyh_-IFmHouv6bPDqbBD8z5likjkfTdYqR36OsuOcs6ZnC_nyXpLBuoeedxnEE6iDjzHQ5vd3EOTSpdzJ3KVcupSIMneZNS_-nuOP4lxeBt6cAMppHgwFGbUhp2k0gXSSozf32l_9p9bWOKOVvaUjxZ2fg8s1SZSRSZBfl2Vadgl6gDXLGfwCOrnHMg</recordid><startdate>20090501</startdate><enddate>20090501</enddate><creator>O’Donovan, A</creator><creator>Lin, J</creator><creator>Dhabhar, F.S</creator><creator>Wolkowitz, O</creator><creator>Tillie, J.M</creator><creator>Blackburn, E</creator><creator>Epel, E</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090501</creationdate><title>Pessimism correlates with leukocyte telomere shortness and elevated interleukin-6 in post-menopausal women</title><author>O’Donovan, A ; Lin, J ; Dhabhar, F.S ; Wolkowitz, O ; Tillie, J.M ; Blackburn, E ; Epel, E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c536t-a4572fd6b527abfdd3e1eb77be392a95e903b26c501959c2013380731ab5fae03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Affect</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging</topic><topic>Aging - blood</topic><topic>Aging - genetics</topic><topic>Aging - immunology</topic><topic>Allergy and Immunology</topic><topic>Attitude</topic><topic>Caregivers</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Health Behavior</topic><topic>Humans</topic><topic>Interleukin-6</topic><topic>Interleukin-6 - blood</topic><topic>Leukocytes - immunology</topic><topic>Leukocytes - metabolism</topic><topic>Middle Aged</topic><topic>Optimism</topic><topic>Patient Selection</topic><topic>Personality - genetics</topic><topic>Personality Inventory</topic><topic>Pessimism</topic><topic>Psychiatry</topic><topic>Regression Analysis</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Stress, Psychological - blood</topic><topic>Stress, Psychological - genetics</topic><topic>Stress, Psychological - immunology</topic><topic>Surveys and Questionnaires</topic><topic>Telomere - genetics</topic><topic>Telomere length</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>O’Donovan, A</creatorcontrib><creatorcontrib>Lin, J</creatorcontrib><creatorcontrib>Dhabhar, F.S</creatorcontrib><creatorcontrib>Wolkowitz, O</creatorcontrib><creatorcontrib>Tillie, J.M</creatorcontrib><creatorcontrib>Blackburn, E</creatorcontrib><creatorcontrib>Epel, E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Brain, behavior, and immunity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>O’Donovan, A</au><au>Lin, J</au><au>Dhabhar, F.S</au><au>Wolkowitz, O</au><au>Tillie, J.M</au><au>Blackburn, E</au><au>Epel, E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pessimism correlates with leukocyte telomere shortness and elevated interleukin-6 in post-menopausal women</atitle><jtitle>Brain, behavior, and immunity</jtitle><addtitle>Brain Behav Immun</addtitle><date>2009-05-01</date><risdate>2009</risdate><volume>23</volume><issue>4</issue><spage>446</spage><epage>449</epage><pages>446-449</pages><issn>0889-1591</issn><eissn>1090-2139</eissn><abstract>Abstract The combination of less positive and more negative expectations for the future (i.e., lower optimism and higher pessimism) increases risk for disease and early mortality. We tested the possibility that expectancies might influence health outcomes by altering the rate of biological aging, specifically of the immune system (immunosenescence). However, no studies to date have examined associations between optimism or pessimism and indicators of immunosenescence such as leukocyte telomere length (TL) and interleukin-6 (IL-6) levels. We investigated whether dispositional tendencies towards optimism and pessimism were associated with TL and IL-6 in a sample of 36 healthy post-menopausal women. Multiple regression analyses where optimism and pessimism were entered simultaneously, and chronological age and caregiver status were controlled, indicated that pessimism was independently associated with shorter TL ( β = −.68, p = .001) and higher IL-6 concentrations ( β = .50, p = .02). In contrast, optimism was not independently associated with either measure of immunosenescence. These findings suggest that dispositional pessimism may increase IL-6 and accelerate rate of telomere shortening. Mechanistic causal relationships between these parameters need to be investigated.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>19111922</pmid><doi>10.1016/j.bbi.2008.11.006</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Affect Aged Aged, 80 and over Aging Aging - blood Aging - genetics Aging - immunology Allergy and Immunology Attitude Caregivers Enzyme-Linked Immunosorbent Assay Female Health Behavior Humans Interleukin-6 Interleukin-6 - blood Leukocytes - immunology Leukocytes - metabolism Middle Aged Optimism Patient Selection Personality - genetics Personality Inventory Pessimism Psychiatry Regression Analysis Reverse Transcriptase Polymerase Chain Reaction Stress, Psychological - blood Stress, Psychological - genetics Stress, Psychological - immunology Surveys and Questionnaires Telomere - genetics Telomere length |
title | Pessimism correlates with leukocyte telomere shortness and elevated interleukin-6 in post-menopausal women |
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