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Dynamic statistical parametric mapping for analyzing ictal magnetoencephalographic spikes in patients with intractable frontal lobe epilepsy
Summary The purpose of this study is to assess the clinical value of spatiotemporal source analysis for analyzing ictal magnetoencephalography (MEG). Ictal MEG and simultaneous scalp EEG was recorded in five patients with medically intractable frontal lobe epilepsy. Dynamic statistical parametric ma...
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Published in: | Epilepsy research 2009-08, Vol.85 (2), p.279-286 |
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container_title | Epilepsy research |
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creator | Tanaka, Naoaki Cole, Andrew J von Pechmann, Deidre Wakeman, Daniel G Hämäläinen, Matti S Liu, Hesheng Madsen, Joseph R Bourgeois, Blaise F Stufflebeam, Steven M |
description | Summary The purpose of this study is to assess the clinical value of spatiotemporal source analysis for analyzing ictal magnetoencephalography (MEG). Ictal MEG and simultaneous scalp EEG was recorded in five patients with medically intractable frontal lobe epilepsy. Dynamic statistical parametric maps (dSPMs) were calculated at the peak of early ictal spikes for the purpose of estimating the spatiotemporal cortical source distribution. DSPM solutions were mapped onto a cortical surface, which was derived from each patient's MRI. Equivalent current dipoles (ECDs) were calculated using a single-dipole model for comparison with dSPMs. In all patients, dSPMs tended to have a localized activation, consistent with the clinically determined ictal onset zone, whereas most ECDs were considered to be inappropriate sources according to their goodness-of-fit values. Analyzing ictal MEG spikes by using dSPMs may provide useful information in presurgical evaluation of epilepsy. |
doi_str_mv | 10.1016/j.eplepsyres.2009.03.023 |
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Ictal MEG and simultaneous scalp EEG was recorded in five patients with medically intractable frontal lobe epilepsy. Dynamic statistical parametric maps (dSPMs) were calculated at the peak of early ictal spikes for the purpose of estimating the spatiotemporal cortical source distribution. DSPM solutions were mapped onto a cortical surface, which was derived from each patient's MRI. Equivalent current dipoles (ECDs) were calculated using a single-dipole model for comparison with dSPMs. In all patients, dSPMs tended to have a localized activation, consistent with the clinically determined ictal onset zone, whereas most ECDs were considered to be inappropriate sources according to their goodness-of-fit values. Analyzing ictal MEG spikes by using dSPMs may provide useful information in presurgical evaluation of epilepsy.</description><identifier>ISSN: 0920-1211</identifier><identifier>EISSN: 1872-6844</identifier><identifier>DOI: 10.1016/j.eplepsyres.2009.03.023</identifier><identifier>PMID: 19394198</identifier><identifier>CODEN: EPIRE8</identifier><language>eng</language><publisher>Kidlington: Elsevier B.V</publisher><subject>Adolescent ; Adult ; Anticonvulsants - therapeutic use ; Anticonvulsants. Antiepileptics. Antiparkinson agents ; Biological and medical sciences ; Brain Mapping ; Cerebral Cortex - abnormalities ; Cerebral Cortex - surgery ; Data Interpretation, Statistical ; Drug Resistance ; Dynamic statistical parametric mapping ; Electroencephalography ; Epilepsy ; Epilepsy, Frontal Lobe - physiopathology ; Epilepsy, Frontal Lobe - surgery ; Female ; Functional Laterality - physiology ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Humans ; Ictal ; Magnetic Resonance Imaging ; Magnetoencephalography ; Magnetoencephalography - statistics & numerical data ; Male ; Medical sciences ; Nervous system (semeiology, syndromes) ; Neurofibromatosis 1 - complications ; Neurology ; Neuropharmacology ; Pharmacology. 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Ictal MEG and simultaneous scalp EEG was recorded in five patients with medically intractable frontal lobe epilepsy. Dynamic statistical parametric maps (dSPMs) were calculated at the peak of early ictal spikes for the purpose of estimating the spatiotemporal cortical source distribution. DSPM solutions were mapped onto a cortical surface, which was derived from each patient's MRI. Equivalent current dipoles (ECDs) were calculated using a single-dipole model for comparison with dSPMs. In all patients, dSPMs tended to have a localized activation, consistent with the clinically determined ictal onset zone, whereas most ECDs were considered to be inappropriate sources according to their goodness-of-fit values. Analyzing ictal MEG spikes by using dSPMs may provide useful information in presurgical evaluation of epilepsy.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Anticonvulsants - therapeutic use</subject><subject>Anticonvulsants. Antiepileptics. Antiparkinson agents</subject><subject>Biological and medical sciences</subject><subject>Brain Mapping</subject><subject>Cerebral Cortex - abnormalities</subject><subject>Cerebral Cortex - surgery</subject><subject>Data Interpretation, Statistical</subject><subject>Drug Resistance</subject><subject>Dynamic statistical parametric mapping</subject><subject>Electroencephalography</subject><subject>Epilepsy</subject><subject>Epilepsy, Frontal Lobe - physiopathology</subject><subject>Epilepsy, Frontal Lobe - surgery</subject><subject>Female</subject><subject>Functional Laterality - physiology</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Humans</subject><subject>Ictal</subject><subject>Magnetic Resonance Imaging</subject><subject>Magnetoencephalography</subject><subject>Magnetoencephalography - statistics & numerical data</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurofibromatosis 1 - complications</subject><subject>Neurology</subject><subject>Neuropharmacology</subject><subject>Pharmacology. 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Antiepileptics. Antiparkinson agents</topic><topic>Biological and medical sciences</topic><topic>Brain Mapping</topic><topic>Cerebral Cortex - abnormalities</topic><topic>Cerebral Cortex - surgery</topic><topic>Data Interpretation, Statistical</topic><topic>Drug Resistance</topic><topic>Dynamic statistical parametric mapping</topic><topic>Electroencephalography</topic><topic>Epilepsy</topic><topic>Epilepsy, Frontal Lobe - physiopathology</topic><topic>Epilepsy, Frontal Lobe - surgery</topic><topic>Female</topic><topic>Functional Laterality - physiology</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Humans</topic><topic>Ictal</topic><topic>Magnetic Resonance Imaging</topic><topic>Magnetoencephalography</topic><topic>Magnetoencephalography - statistics & numerical data</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurofibromatosis 1 - complications</topic><topic>Neurology</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Retrospective Studies</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tanaka, Naoaki</creatorcontrib><creatorcontrib>Cole, Andrew J</creatorcontrib><creatorcontrib>von Pechmann, Deidre</creatorcontrib><creatorcontrib>Wakeman, Daniel G</creatorcontrib><creatorcontrib>Hämäläinen, Matti S</creatorcontrib><creatorcontrib>Liu, Hesheng</creatorcontrib><creatorcontrib>Madsen, Joseph R</creatorcontrib><creatorcontrib>Bourgeois, Blaise F</creatorcontrib><creatorcontrib>Stufflebeam, Steven M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Epilepsy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tanaka, Naoaki</au><au>Cole, Andrew J</au><au>von Pechmann, Deidre</au><au>Wakeman, Daniel G</au><au>Hämäläinen, Matti S</au><au>Liu, Hesheng</au><au>Madsen, Joseph R</au><au>Bourgeois, Blaise F</au><au>Stufflebeam, Steven M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dynamic statistical parametric mapping for analyzing ictal magnetoencephalographic spikes in patients with intractable frontal lobe epilepsy</atitle><jtitle>Epilepsy research</jtitle><addtitle>Epilepsy Res</addtitle><date>2009-08-01</date><risdate>2009</risdate><volume>85</volume><issue>2</issue><spage>279</spage><epage>286</epage><pages>279-286</pages><issn>0920-1211</issn><eissn>1872-6844</eissn><coden>EPIRE8</coden><abstract>Summary The purpose of this study is to assess the clinical value of spatiotemporal source analysis for analyzing ictal magnetoencephalography (MEG). Ictal MEG and simultaneous scalp EEG was recorded in five patients with medically intractable frontal lobe epilepsy. Dynamic statistical parametric maps (dSPMs) were calculated at the peak of early ictal spikes for the purpose of estimating the spatiotemporal cortical source distribution. DSPM solutions were mapped onto a cortical surface, which was derived from each patient's MRI. Equivalent current dipoles (ECDs) were calculated using a single-dipole model for comparison with dSPMs. In all patients, dSPMs tended to have a localized activation, consistent with the clinically determined ictal onset zone, whereas most ECDs were considered to be inappropriate sources according to their goodness-of-fit values. Analyzing ictal MEG spikes by using dSPMs may provide useful information in presurgical evaluation of epilepsy.</abstract><cop>Kidlington</cop><pub>Elsevier B.V</pub><pmid>19394198</pmid><doi>10.1016/j.eplepsyres.2009.03.023</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adolescent Adult Anticonvulsants - therapeutic use Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Brain Mapping Cerebral Cortex - abnormalities Cerebral Cortex - surgery Data Interpretation, Statistical Drug Resistance Dynamic statistical parametric mapping Electroencephalography Epilepsy Epilepsy, Frontal Lobe - physiopathology Epilepsy, Frontal Lobe - surgery Female Functional Laterality - physiology Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Ictal Magnetic Resonance Imaging Magnetoencephalography Magnetoencephalography - statistics & numerical data Male Medical sciences Nervous system (semeiology, syndromes) Neurofibromatosis 1 - complications Neurology Neuropharmacology Pharmacology. Drug treatments Retrospective Studies Young Adult |
title | Dynamic statistical parametric mapping for analyzing ictal magnetoencephalographic spikes in patients with intractable frontal lobe epilepsy |
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