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Dynamic statistical parametric mapping for analyzing ictal magnetoencephalographic spikes in patients with intractable frontal lobe epilepsy

Summary The purpose of this study is to assess the clinical value of spatiotemporal source analysis for analyzing ictal magnetoencephalography (MEG). Ictal MEG and simultaneous scalp EEG was recorded in five patients with medically intractable frontal lobe epilepsy. Dynamic statistical parametric ma...

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Published in:Epilepsy research 2009-08, Vol.85 (2), p.279-286
Main Authors: Tanaka, Naoaki, Cole, Andrew J, von Pechmann, Deidre, Wakeman, Daniel G, Hämäläinen, Matti S, Liu, Hesheng, Madsen, Joseph R, Bourgeois, Blaise F, Stufflebeam, Steven M
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creator Tanaka, Naoaki
Cole, Andrew J
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Stufflebeam, Steven M
description Summary The purpose of this study is to assess the clinical value of spatiotemporal source analysis for analyzing ictal magnetoencephalography (MEG). Ictal MEG and simultaneous scalp EEG was recorded in five patients with medically intractable frontal lobe epilepsy. Dynamic statistical parametric maps (dSPMs) were calculated at the peak of early ictal spikes for the purpose of estimating the spatiotemporal cortical source distribution. DSPM solutions were mapped onto a cortical surface, which was derived from each patient's MRI. Equivalent current dipoles (ECDs) were calculated using a single-dipole model for comparison with dSPMs. In all patients, dSPMs tended to have a localized activation, consistent with the clinically determined ictal onset zone, whereas most ECDs were considered to be inappropriate sources according to their goodness-of-fit values. Analyzing ictal MEG spikes by using dSPMs may provide useful information in presurgical evaluation of epilepsy.
doi_str_mv 10.1016/j.eplepsyres.2009.03.023
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identifier ISSN: 0920-1211
ispartof Epilepsy research, 2009-08, Vol.85 (2), p.279-286
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source Elsevier
subjects Adolescent
Adult
Anticonvulsants - therapeutic use
Anticonvulsants. Antiepileptics. Antiparkinson agents
Biological and medical sciences
Brain Mapping
Cerebral Cortex - abnormalities
Cerebral Cortex - surgery
Data Interpretation, Statistical
Drug Resistance
Dynamic statistical parametric mapping
Electroencephalography
Epilepsy
Epilepsy, Frontal Lobe - physiopathology
Epilepsy, Frontal Lobe - surgery
Female
Functional Laterality - physiology
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Humans
Ictal
Magnetic Resonance Imaging
Magnetoencephalography
Magnetoencephalography - statistics & numerical data
Male
Medical sciences
Nervous system (semeiology, syndromes)
Neurofibromatosis 1 - complications
Neurology
Neuropharmacology
Pharmacology. Drug treatments
Retrospective Studies
Young Adult
title Dynamic statistical parametric mapping for analyzing ictal magnetoencephalographic spikes in patients with intractable frontal lobe epilepsy
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