Bell's palsy and choreiform movements during peginterferon alpha and ribavirin therapy

Neuropsychiatric side effects of long-term recombinant interferon-alpha therapy consist of a large spectrum of symptoms. In the literature, cranial neuropathy, especially Bell's palsy, and movement disorders, have been reported much less often than other neurotoxic effects. We report a case of...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2009-08, Vol.15 (29), p.3694-3696
Main Authors: Barut, Sener, Karaer, Hatice, Oksuz, Erol, Eken, Asli Gündoğdu, Basak, Ayse Nazli
Format: Article
Language:English
Subjects:
Antiviral Agents - adverse effects
Bell Palsy - chemically induced
Case Report
Chorea - chemically induced
Female
Hepatitis C - drug therapy
Humans
Interferon alpha-2
Interferon-alpha - adverse effects
Middle Aged
Polyethylene Glycols - adverse effects
Recombinant Proteins
Ribavirin - adverse effects
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Summary:Neuropsychiatric side effects of long-term recombinant interferon-alpha therapy consist of a large spectrum of symptoms. In the literature, cranial neuropathy, especially Bell's palsy, and movement disorders, have been reported much less often than other neurotoxic effects. We report a case of Bell's palsy in a patient with chronic hepatitis C during peginterferon-alpha and ribavirin therapy. The patient subsequently developed clinically inapparent facial nerve involvement on the contralateral side and showed an increase in choreic movements related to Huntington's disease during treatment.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.15.3694