Impact of the metabolic syndrome on aortic pulse pressure and ascending aortic pulsatility in patients with angiographically normal coronary arteries

• Published in: Canadian journal of cardiology 2009-07, Vol.25 (7), p.411-414
• Main Authors: Emre, Ayse, MD FACC, Oz, Dilaver, MD, Yesilcimen, Kemal, MD, Sayar, Nurten, MD, Ergun, Dilek, MD
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Aorta - pathology; Aortic stiffness; Blood Pressure; Cardiovascular; Case-Control Studies; Clinical Studies; Compliance; Coronary Vessels - pathology; Fasting; Female; Humans; Male; Metabolic syndrome; Metabolic Syndrome - diagnosis; Metabolic Syndrome - physiopathology; Middle Aged; Multivariate Analysis; Pulsatile Flow; Reference Values; Regression Analysis; Systole; Waist Circumference
• ISSN: 0828-282X; 1916-7075
• DOI: 10.1016/S0828-282X(09)70504-5

Background Large artery stiffness is a major determinant of pulse pressure (PP), and PP at baseline has been associated with future coronary events. Objective To evaluate the impact of the metabolic syndrome on aortic PP and ascending aortic pulsatility (AP) in patients with angiographically normal coronary arteries. Methods Forty-two patients with the metabolic syndrome and 40 agematched control subjects without the metabolic syndrome were included in the study. All subjects had normal coronary arteries. Diagnosis of the metabolic syndrome was based on the International Diabetes Federation guidelines published in 2005. Ascending AP was estimated as the ratio of aortic PP to mean blood pressure. Results Aortic PP (59±12 mmHg versus 43 ± 10 mmHg; P < 0.001) and ascending AP (0.54±0.10 versus 0.48±0.10; P