Maternal and foetal outcomes in pregnant patients with active lupus nephritis

The objective of this study was to determine the impact of lupus nephritis disease activity on maternal and foetal outcomes in pregnant patients with systemic lupus erythematosus (SLE). Medical records of all pregnant patients with SLE treated at our institution between 1976 and 2007 were reviewed....

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Bibliographic Details
Published in:Lupus 2009-04, Vol.18 (4), p.342-347
Main Authors: Wagner, SJ, Craici, I, Reed, D, Norby, S, Bailey, K, Wiste, HJ, Wood, CM, Moder, KG, Liang, KP, Liang, KV, Rose, C, Rozkos, T, Sitina, M, Grande, JP, Garovic, VD
Format: Article
Language:English
Subjects:
Adult
Classification
Creatinine
Creatinine - blood
Female
Fetal Death - epidemiology
Fetal Death - etiology
Humans
Hypertension
Lupus
Lupus Erythematosus, Systemic - complications
Lupus Erythematosus, Systemic - physiopathology
Lupus Nephritis - complications
Lupus Nephritis - physiopathology
Medical records
Nephrology
Pregnancy
Pregnancy Complications - etiology
Pregnancy Outcome
Premature Birth - epidemiology
Premature Birth - etiology
Proteinuria - etiology
Remission (Medicine)
Retrospective Studies
Rheumatology
Womens health
Young Adult
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Summary:The objective of this study was to determine the impact of lupus nephritis disease activity on maternal and foetal outcomes in pregnant patients with systemic lupus erythematosus (SLE). Medical records of all pregnant patients with SLE treated at our institution between 1976 and 2007 were reviewed. All patients met American College of Rheumatology classification criteria for SLE. Demographic data, history of lupus nephritis, nephritis disease activity and maternal and foetal outcomes of pregnancy were abstracted. Active lupus nephritis was defined as the presence of proteinuria >0.5 g/day and/or active urinary sediment with or without an elevation in serum creatinine (Cr). Quiescent lupus nephritis was confirmed in the presence of proteinuria
ISSN:0961-2033
1477-0962
DOI:10.1177/0961203308097575