Dietary activators of Sirt1

Calorie restriction (CR) is a non-genetic manipulation that reliably results in extended lifespan of several species ranging from yeast to dogs. The lifespan extension effect of CR has been strongly associated with an increased level and activation of the silent information regulator 2 (Sir2) histon...

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Bibliographic Details
Published in:Molecular and cellular endocrinology 2009-02, Vol.299 (1), p.58-63
Main Authors: Allard, Joanne S., Perez, Evelyn, Zou, Sige, de Cabo, Rafael
Format: Article
Language:English
Subjects:
Activation
Animals
Caenorhabditis elegans - metabolism
Caenorhabditis elegans - physiology
Caloric Restriction
Calorie restriction
Cellular
Constrictions
Diet
Dietary Supplements
Dogs
Drosophila melanogaster - metabolism
Drosophila melanogaster - physiology
Endocrinology
Enzyme Activation - drug effects
Flavonoids - pharmacology
Histone Deacetylases - metabolism
Histones
Humans
Lifespan
Phenols - pharmacology
Polyphenols
Regulators
Resveratrol
Saccharomyces cerevisiae - metabolism
Saccharomyces cerevisiae - physiology
Searching
Sirtuins
Sirtuins - metabolism
Vertebrates - metabolism
Vertebrates - physiology
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Summary:Calorie restriction (CR) is a non-genetic manipulation that reliably results in extended lifespan of several species ranging from yeast to dogs. The lifespan extension effect of CR has been strongly associated with an increased level and activation of the silent information regulator 2 (Sir2) histone deacetylase and its mammalian ortholog Sirt1. This association led to the search for potential Sirt1-activating, life-extending molecules. This review briefly outlines the experimental findings on resveratrol and other dietary activators of Sirt1.
ISSN:0303-7207
1872-8057
DOI:10.1016/j.mce.2008.10.018