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Dietary activators of Sirt1
Calorie restriction (CR) is a non-genetic manipulation that reliably results in extended lifespan of several species ranging from yeast to dogs. The lifespan extension effect of CR has been strongly associated with an increased level and activation of the silent information regulator 2 (Sir2) histon...
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| Published in: | Molecular and cellular endocrinology 2009-02, Vol.299 (1), p.58-63 |
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| cites | cdi_FETCH-LOGICAL-c481t-1acd1c57be5b678fc6ecc12ef9717d5aaf9064d18580ec4e2e6dbdf9a6e1b4923 |
| container_end_page | 63 |
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| container_title | Molecular and cellular endocrinology |
| container_volume | 299 |
| creator | Allard, Joanne S. Perez, Evelyn Zou, Sige de Cabo, Rafael |
| description | Calorie restriction (CR) is a non-genetic manipulation that reliably results in extended lifespan of several species ranging from yeast to dogs. The lifespan extension effect of CR has been strongly associated with an increased level and activation of the silent information regulator 2 (Sir2) histone deacetylase and its mammalian ortholog Sirt1. This association led to the search for potential Sirt1-activating, life-extending molecules. This review briefly outlines the experimental findings on resveratrol and other dietary activators of Sirt1. |
| doi_str_mv | 10.1016/j.mce.2008.10.018 |
| format | article |
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This review briefly outlines the experimental findings on resveratrol and other dietary activators of Sirt1.</description><subject>Activation</subject><subject>Animals</subject><subject>Caenorhabditis elegans - metabolism</subject><subject>Caenorhabditis elegans - physiology</subject><subject>Caloric Restriction</subject><subject>Calorie restriction</subject><subject>Cellular</subject><subject>Constrictions</subject><subject>Diet</subject><subject>Dietary Supplements</subject><subject>Dogs</subject><subject>Drosophila melanogaster - metabolism</subject><subject>Drosophila melanogaster - physiology</subject><subject>Endocrinology</subject><subject>Enzyme Activation - drug effects</subject><subject>Flavonoids - pharmacology</subject><subject>Histone Deacetylases - metabolism</subject><subject>Histones</subject><subject>Humans</subject><subject>Lifespan</subject><subject>Phenols - pharmacology</subject><subject>Polyphenols</subject><subject>Regulators</subject><subject>Resveratrol</subject><subject>Saccharomyces cerevisiae - metabolism</subject><subject>Saccharomyces cerevisiae - physiology</subject><subject>Searching</subject><subject>Sirtuins</subject><subject>Sirtuins - metabolism</subject><subject>Vertebrates - metabolism</subject><subject>Vertebrates - physiology</subject><issn>0303-7207</issn><issn>1872-8057</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LAzEQhoMotlZ_gAjSk562zmR3kyyCIPUTCh7Uc8hmZzVl29VkW_Dfm9Lix6WnMJlnXmYexo4RRggoLqajmaURB1CxHgGqHdZHJXmiIJe7rA8ppInkIHvsIIQpAMicq33WwwIQUiX67OTGUWf819DYzi1N1_owbOvhs_MdHrK92jSBjjbvgL3e3b6MH5LJ0_3j-HqS2Exhl6CxFdpclpSXQqraCrIWOdWFRFnlxtQFiKxClSsgmxEnUZVVXRhBWGYFTwfsap37sShnVFmad940-sO7WdxMt8bp_525e9dv7VJzyaUQRQw43wT49nNBodMzFyw1jZlTuwhaFYKnIHkeybOtpBAqz5TMIohr0Po2BE_1zzoIeiVfT3WUr1fyV19Rfpw5_XvH78TGdgQu1wBFm0tHXgfraG6pcp5sp6vWbYn_BuKIlN4</recordid><startdate>20090205</startdate><enddate>20090205</enddate><creator>Allard, Joanne S.</creator><creator>Perez, Evelyn</creator><creator>Zou, Sige</creator><creator>de Cabo, Rafael</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><scope>5PM</scope></search><sort><creationdate>20090205</creationdate><title>Dietary activators of Sirt1</title><author>Allard, Joanne S. ; 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| identifier | ISSN: 0303-7207 |
| ispartof | Molecular and cellular endocrinology, 2009-02, Vol.299 (1), p.58-63 |
| issn | 0303-7207 1872-8057 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2727669 |
| source | ScienceDirect Journals |
| subjects | Activation Animals Caenorhabditis elegans - metabolism Caenorhabditis elegans - physiology Caloric Restriction Calorie restriction Cellular Constrictions Diet Dietary Supplements Dogs Drosophila melanogaster - metabolism Drosophila melanogaster - physiology Endocrinology Enzyme Activation - drug effects Flavonoids - pharmacology Histone Deacetylases - metabolism Histones Humans Lifespan Phenols - pharmacology Polyphenols Regulators Resveratrol Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae - physiology Searching Sirtuins Sirtuins - metabolism Vertebrates - metabolism Vertebrates - physiology |
| title | Dietary activators of Sirt1 |
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