Nitrosative and oxidative stress responses in fungal pathogenicity

Fungal pathogenicity has arisen in polyphyletic manner during evolution, yielding fungal pathogens with diverse infection strategies and with differing degrees of evolutionary adaptation to their human host. Not surprisingly, these fungal pathogens display differing degrees of resistance to the reac...

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Published in:Current opinion in microbiology 2009-08, Vol.12 (4), p.384-391
Main Authors: Brown, Alistair JP, Haynes, Ken, Quinn, Janet
Format: Article
Language:English
Subjects:
Antifungal Agents - pharmacology
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Fungi - pathogenicity
Fungi - physiology
Host-Pathogen Interactions
Humans
Microbiology
Models, Biological
Nitroso Compounds - pharmacology
Oxidants - pharmacology
Oxidative Stress
Pathology
Stress, Physiological
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description Fungal pathogenicity has arisen in polyphyletic manner during evolution, yielding fungal pathogens with diverse infection strategies and with differing degrees of evolutionary adaptation to their human host. Not surprisingly, these fungal pathogens display differing degrees of resistance to the reactive oxygen and nitrogen species used by human cells to counteract infection. Furthermore, whilst evolutionarily conserved regulators, such as Hog1, are central to such stress responses in many fungal pathogens, species-specific differences in their roles and regulation abound. In contrast, there is a high degree of commonality in the cellular responses to reactive oxygen and nitrogen species evoked in evolutionarily divergent fungal pathogens.
doi_str_mv 10.1016/j.mib.2009.06.007
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source ScienceDirect Journals
subjects Antifungal Agents - pharmacology
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Fungi - pathogenicity
Fungi - physiology
Host-Pathogen Interactions
Humans
Microbiology
Models, Biological
Nitroso Compounds - pharmacology
Oxidants - pharmacology
Oxidative Stress
Pathology
Stress, Physiological
title Nitrosative and oxidative stress responses in fungal pathogenicity
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