Serum 25-Hydroxyvitamin D Concentration and Cognitive Impairment

Vitamin D may be of interest in the prevention of cognitive impairment, though previous findings are inconclusive. Participants were 1766 adults aged 65 years and older from the Health Survey for England 2000, a nationally representative population-based study. Cognitive impairment was assessed usin...

Full description

Saved in:
Bibliographic Details
Published in:Journal of geriatric psychiatry and neurology 2009-09, Vol.22 (3), p.188-195
Main Authors: Llewellyn, David J., Langa, Kenneth M., Lang, Iain A.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biological and medical sciences
Cognition Disorders - blood
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Female
Fundamental and applied biological sciences. Psychology
Geriatrics
Humans
Linear Models
Logistic Models
Male
Medical sciences
Neurology
Neuropsychological Tests
Odds Ratio
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Vertebrates: nervous system and sense organs
Vitamin D - analogs & derivatives
Vitamin D - blood
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Vitamin D may be of interest in the prevention of cognitive impairment, though previous findings are inconclusive. Participants were 1766 adults aged 65 years and older from the Health Survey for England 2000, a nationally representative population-based study. Cognitive impairment was assessed using the Abbreviated Mental Test Score. The cross-sectional relation of serum 25-hydroxyvitamin D quartiles to cognitive impairment was modeled using logistic regression. In all, 212 participants (12%) were cognitively impaired. Odds ratios (95% confidence intervals) for cognitive impairment in the first (8-30 nmol/L), second (31-44 nmol/L), and third (45-65 nmol/L) quartiles of serum 25-hydroxyvitamin D compared with the fourth (66-170 nmol/L) were 2.3 (1.4-3.8), 1.4 (0.8-2.4), and 1.1 (0.6-1.9), after adjustment for age, sex, education, ethnicity, season of testing, and additional risk factors for cognitive impairment (P for linear trend = .001). Our data suggest low serum 25-hydroxyvitamin D is associated with increased odds of cognitive impairment.
ISSN:0891-9887
1552-5708
DOI:10.1177/0891988708327888