Parvovirus B19 induced hepatic failure in an adult requiring liver transplantation

• Published in: World journal of gastroenterology : WJG 2009-08, Vol.15 (32), p.4067-4069
• Main Authors: Krygier, Darin S, Steinbrecher, Urs P, Petric, Martin, Erb, Siegfried R, Chung, Stephen W, Scudamore, Charles H, Buczkowski, Andrzej K, Yoshida, Eric M
• Format: Article
• Language: English
• Subjects: Acute Disease; Case Report; DNA, Viral - metabolism; Female; Hepatitis - therapy; Hepatitis - virology; Humans; Liver Failure, Acute - therapy; Liver Failure, Acute - virology; Liver Transplantation - methods; Middle Aged; Parvoviridae Infections - therapy; Parvoviridae Infections - virology; Parvovirus B19, Human - metabolism; Polymerase Chain Reaction; Treatment Outcome; 免疫能力; 急性感染; 暴发性; 细小病毒B19; 肝功能衰竭; 肝移植; 血液系统
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.15.4067

Parvovirus B19 induced acute hepatitis and hepatic failure have been previously reported, mainly in children. Very few cases of parvovirus induced hepatic failure have been reported in adults and fewer still have required liver transplantation. We report the case of a 55-year-old immunocompetent woman who developed fulminant hepatic failure after acute infection with Parvovirus B19 who subsequently underwent orthotopic liver transplantation. This is believed to be the first reported case in the literature in which an adult patient with fulminant hepatic failure associated with acute parvovirus B19 infection and without hematologic abnormalities has been identified prior to undergoing liver transplantation. This case suggests that Parvovirus B19 induced liver disease can affect adults, can occur in the absence of hematologic abnormalities and can be severe enough to require liver transplantation.