pRb and condensin--local control of global chromosome structure

Rb mutants exhibit aneuploidy and aberrant chromosome structure during mitosis. In this issue of Genes & Development, a new paper from Longworth and colleagues (1011-1024) describes both physical and functional interactions between Drosophila Rbf1 and the dCAP-D3 subunit of condensin II. This wo...

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Bibliographic Details
Published in:Genes & development 2008-04, Vol.22 (8), p.964-969
Main Author: Lavoie, Brigitte D
Format: Article
Language:English
Subjects:
Adenosine Triphosphatases - metabolism
Animals
Chromosome Structures - metabolism
DNA-Binding Proteins - metabolism
Drosophila
Drosophila Proteins - genetics
Drosophila Proteins - metabolism
Humans
Mitosis
Models, Biological
Multiprotein Complexes - metabolism
Retinoblastoma Protein - genetics
Retinoblastoma Protein - metabolism
Transcription Factors - metabolism
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Summary:Rb mutants exhibit aneuploidy and aberrant chromosome structure during mitosis. In this issue of Genes & Development, a new paper from Longworth and colleagues (1011-1024) describes both physical and functional interactions between Drosophila Rbf1 and the dCAP-D3 subunit of condensin II. This work directly implicates the Rb family proteins in mitotic chromosome condensation and suggests that a failure in targeting condensin II to chromatin underlies the aneuploidy in rbf1 mutants.
ISSN:0890-9369
1549-5477
DOI:10.1101/gad.1666808