Occult left ventricular dysfunction diagnosed by myocardial performance index in patients with limb girdle muscle dystrophy: A case control study

• Published in: The International journal of angiology 2007-09, Vol.16 (4), p.139-142
• Main Authors: Gurrala, Rajashekar R, Alla, Venkata MB, Aronow, Wilbert S, Shankar, Jai S, Angamutta, Meena K, Lanka, Krishna SR, Challa, Sundaram, Nair, Chandra K
• Format: Article
• Language: English
• Subjects: Original; Original Articles
• ISSN: 1061-1711; 1615-5939
• DOI: 10.1055/s-0031-1278268

Abstract RR Gurrala, VMB Alla, WS Aronow, et al. Occult left ventricular dysfunction diagnosed by myocardial performance index in patients with limb girdle muscle dystrophy: A case control study. Int J Angiol 2007;16(4):139-142. The myocardial performance index (MPI) was assessed in 30 patients with limb girdle muscle dystrophy (LGMD) with a normal left ventricular ejection fraction (greater than 50%), as well as in 30 age- and sex-matched healthy adults with a left ventricular ejection fraction greater than 50%. MPIs derived by pulsed-wave Doppler and tissue Doppler were also compared. The MPI was 0.37±0.09 in the LGMD patients and 0.29±0.09 in the control group (P=0.003). These data show that patients with LGMD have occult cardiac dysfunction as evidenced by a higher MPI than the controls. There was good agreement between the MPIs measured by pulsed-wave Doppler and tissue Doppler methods in these patients.