Activity Energy Expenditure and Mobility Limitation in Older Adults: Differential Associations by Sex

In this study, the authors aimed to determine whether higher activity energy expenditure, assessed by using doubly labeled water, was associated with a reduced decline in mobility limitation among 248 older community-dwelling US adults aged 70–82 years enrolled in 1998–1999. Activity energy expendit...

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Bibliographic Details
Published in:American journal of epidemiology 2009-06, Vol.169 (12), p.1507-1516
Main Authors: Manini, Todd M., Everhart, James E., Patel, Kushang V., Schoeller, Dale A., Cummings, Steve, Mackey, Dawn C., Bauer, Douglas C., Simonsick, Eleanor M., Colbert, Lisa H., Visser, Marjolein, Tylavsky, Frances, Newman, Anne B., Harris, Tamara B.
Format: Article
Language:English
Subjects:
Activities of Daily Living
Age Factors
Aged
Aged, 80 and over
aging
Aging - physiology
Analysis. Health state
Biological and medical sciences
Calorimetry
Confidence Intervals
Disability Evaluation
Energy Metabolism
Epidemiology
Exercise
Female
Gait - physiology
Gender differences
General aspects
Health Status
Humans
Longitudinal Studies
Male
Medical sciences
Mobility
Mobility Limitation
motor activity
Motor Activity - physiology
Older people
Original Contributions
Proportional Hazards Models
Public health. Hygiene
Public health. Hygiene-occupational medicine
sex
Sex Factors
Surveys and Questionnaires
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Summary:In this study, the authors aimed to determine whether higher activity energy expenditure, assessed by using doubly labeled water, was associated with a reduced decline in mobility limitation among 248 older community-dwelling US adults aged 70–82 years enrolled in 1998–1999. Activity energy expenditure was calculated as total energy expenditure (assessed over 2 weeks by using doubly labeled water) minus resting metabolic rate (measured with indirect calorimetry), with adjustment for the thermic effect of food. Across sex-specific tertiles of activity energy expenditure, men in the lowest activity group experienced twice the rate of mobility limitation as men in the highest activity group (41% (n = 18) vs. 18% (n = 8)). Conversely, women in the lowest and highest activity groups exhibited similarly high rates of mobility limitation (40% (n = 16) vs. 38% (n = 15)). After adjustment for potential confounders, men with higher activity energy expenditure levels continued to show reduced risk of mobility limitation (per standard deviation (284 kcal/day): hazard ratio = 0.61, 95% confidence interval: 0.41, 0.92). Women showed no association (per standard deviation (226 kcal/day): hazard ratio = 1.34, 95% confidence interval: 0.98, 1.85). Greater energy expenditure from any and all physical activity was significantly associated with reduced risk of developing mobility limitation among men, but not among women.
ISSN:0002-9262
1476-6256
DOI:10.1093/aje/kwp069