Nerve growth factor attenuates proliferation of astrocytes via the p75 neurotrophin receptor

The p75 neurotrophin receptor has been implicated in the regulation of multiple cellular functions that differ depending on the cell context. We have observed that p75NTR is strongly induced on astrocytes as well as neurons in the hippocampal CA3 region after seizures; however, the function of this...

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Bibliographic Details
Published in:Glia 2009-10, Vol.57 (13), p.1386-1392
Main Authors: Cragnolini, Andrea B., Huang, Yangyang, Gokina, Pradeepa, Friedman, Wilma J.
Format: Article
Language:English
Subjects:
Animals
Apoptosis - physiology
Astrocytes - cytology
Astrocytes - physiology
Cell Count
cell cycle
Cell Proliferation
Cells, Cultured
Hippocampus - cytology
Hippocampus - physiology
Male
Mitogens - metabolism
Nerve Growth Factor - metabolism
Neurons - physiology
NGF
Pilocarpine
Rats
Rats, Sprague-Dawley
Receptors, Nerve Growth Factor - metabolism
RNA, Messenger - metabolism
seizures
Seizures - chemically induced
Seizures - physiopathology
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Summary:The p75 neurotrophin receptor has been implicated in the regulation of multiple cellular functions that differ depending on the cell context. We have observed that p75NTR is strongly induced on astrocytes as well as neurons in the hippocampal CA3 region after seizures; however, the function of this receptor on these glial cells has not been defined. We have employed a primary culture system to investigate the effects of neurotrophins on astrocytes. Treatment of hippocampal astrocytes with nerve growth factor (NGF) caused a reduction in cell number, but did not elicit an apoptotic response, in contrast to hippocampal neurons. Instead, activation of p75NTR by NGF attenuated proliferation induced by mitogens such as EGF or serum. These studies demonstrate the cell type specificity of neurotrophin functions in the brain. © 2009 Wiley‐Liss, Inc.
ISSN:0894-1491
1098-1136
DOI:10.1002/glia.20857