Variant in RGS2 moderates posttraumatic stress symptoms following potentially traumatic event exposure

Abstract Polymorphisms in the RGS2 (regulator of G-protein signaling 2) gene were found to be associated with anxious behavior in mice and anxiety in humans. We examined whether rs4606, a single nucleotide polymorphism (SNP) of RGS2 , and social support moderated risk for PTSD in an epidemiologic sa...

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Published in:Journal of anxiety disorders 2009-04, Vol.23 (3), p.369-373
Main Authors: Amstadter, Ananda B, Koenen, Karestan C, Ruggiero, Kenneth J, Acierno, Ron, Galea, Sandro, Kilpatrick, Dean G, Gelernter, Joel
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Anxiety disorders. Neuroses
Biological and medical sciences
Candidate gene
Cyclonic Storms
Environmental aspects
Female
Genetic by environment interaction
Genetics
Genotype
Humans
Life Change Events
Male
Medical sciences
Polymorphism, Genetic - genetics
Post-traumatic stress disorder
Posttraumatic stress disorder
Prevalence
Psychiatry
Psychological trauma
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
RGS Proteins - genetics
RGS2
Risk Factors
Social Support
Stress Disorders, Post-Traumatic - epidemiology
Stress Disorders, Post-Traumatic - genetics
Stress Disorders, Post-Traumatic - psychology
Trauma
Traumatic life events
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Summary:Abstract Polymorphisms in the RGS2 (regulator of G-protein signaling 2) gene were found to be associated with anxious behavior in mice and anxiety in humans. We examined whether rs4606, a single nucleotide polymorphism (SNP) of RGS2 , and social support moderated risk for PTSD in an epidemiologic sample. The study examines 607 adults from the 2004 Florida Hurricanes study who returned buccal DNA samples via mail. rs4606 was associated with increased symptoms of posthurricane PTSD symptoms under conditions of high hurricane exposure and low social support ( P < .05). Further, this polymorphism was associated with lifetime PTSD symptoms under conditions of lifetime exposure to a potentially traumatic event, and low social support ( P < .001). These gene by environment interactions remained significant after adjustment for sex, ancestry, and age. RGS2 rs4606 modifies risk of postdisaster and lifetime PTSD symptoms under conditions of high stressor exposure. This is the first demonstration of gene–environment interaction for this locus.
ISSN:0887-6185
1873-7897
DOI:10.1016/j.janxdis.2008.12.005