Limb use and complex ultrasonic vocalization in a rat model of Parkinson's disease: Deficit-targeted training

Abstract Recent evidence in animal models of Parkinson's disease (PD) suggests that exercise and other forms of motor enhancement can be beneficial when applied during the degeneration of dopamine neurons. Behaviours that depend on adequate levels of striatal dopamine may provide particularly f...

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Bibliographic Details
Published in:Parkinsonism & related disorders 2008-01, Vol.14 (Suppl 2), p.S172-S175
Main Authors: Ciucci, Michelle R, Ma, Sean T, Kane, Jacqueline R, Ahrens, Allison M, Schallert, Timothy
Format: Article
Language:English
Subjects:
Animals
Behavior, Animal
Disease Models, Animal
Dopamine
Extremities - physiopathology
Humans
Neurology
Parkinson Disease - complications
Parkinson Disease - rehabilitation
Parkinsonism
Perceptual Disorders - diagnosis
Perceptual Disorders - etiology
Perceptual Disorders - rehabilitation
Rats
Rehabilitation
Sensorimotor
Ultrasonics
Ultrasound call
Vocalization, Animal - physiology
Voice
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Summary:Abstract Recent evidence in animal models of Parkinson's disease (PD) suggests that exercise and other forms of motor enhancement can be beneficial when applied during the degeneration of dopamine neurons. Behaviours that depend on adequate levels of striatal dopamine may provide particularly favourable targets for therapeutic motor interventions. Task-specific motor enrichment procedures have been used to improve functional and neural outcomes following unilateral infusions of 6-hydroxydopamine (6-OHDA) into the nigrostriatal pathway in rats. In contrast, forced non-use procedures can exaggerate the degree of degeneration. Limb-use akinesia and ultrasonic vocalization in the 50-kHz range may be useful behavioural indices of nigrostriatal integrity and may model common deficits found in PD. These deficits in movement initiation and fine sensorimotor control are potential targets for early training interventions.
ISSN:1353-8020
1873-5126
DOI:10.1016/j.parkreldis.2008.04.027