Dietary Manipulation of Histone Structure and Function

Post-translational modifications of histones are the subject of intensive investigations with the aim of decoding how they regulate, alone or in combination, chromatin structure, genomic stability, and gene expression. Major epigenetic programming events take place during gametogenesis and fetal dev...

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Bibliographic Details
Published in:Annual review of nutrition 2008-01, Vol.28 (1), p.347-366
Main Authors: Delage, Barbara, Dashwood, Roderick H
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
chemical structure
chromatin
diet
disease prevention
DNA Methylation
Embryology: invertebrates and vertebrates. Teratology
epidemiology
Epigenesis, Genetic
epigenetics
Female
fetal development
Fetal Nutrition Disorders - genetics
functional properties
Fundamental and applied biological sciences. Psychology
gametogenesis
gene expression
Gene Expression Regulation
Gene Expression Regulation, Developmental
Gene Silencing
genome
histones
Histones - metabolism
Humans
literature reviews
Male
maternal nutrition
Maternal Nutritional Physiological Phenomena - genetics
Maternal Nutritional Physiological Phenomena - physiology
Molecular embryology
neoplasms
post-translational modification
Pregnancy
prenatal development
Prenatal Exposure Delayed Effects
Prenatal Nutritional Physiological Phenomena - genetics
Prenatal Nutritional Physiological Phenomena - physiology
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Summary:Post-translational modifications of histones are the subject of intensive investigations with the aim of decoding how they regulate, alone or in combination, chromatin structure, genomic stability, and gene expression. Major epigenetic programming events take place during gametogenesis and fetal development and are thought to have long-lasting consequences on adult health. Epidemiological and experimental studies have pointed toward maternal nutrition as a major player during prenatal development in influencing disease susceptibility later in life. Although the mechanisms underlying such observations are not well elucidated, epigenetic alterations of histones by particular maternal diets might be of central importance. Moreover, as much as dietary sources can influence epigenetic programming during pregnancy, they have started to be implicated in cancer chemoprevention, via the targeting of reversible epigenetic deregulations at the level of the histones.
ISSN:0199-9885
1545-4312
DOI:10.1146/annurev.nutr.28.061807.155354