Paclitaxel induces nucleolar enlargement in dorsal root ganglion neurons in vivo reducing oxaliplatin toxicity

Paclitaxel and oxaliplatin are promising drugs for combination trials but both induce peripheral neurotoxicity. To investigate this toxicity, 10-week-old female Wistar rats were given single intraperitoneal doses of paclitaxel and oxaliplatin, alone or in combination. Neurotoxicity was assessed by L...

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Bibliographic Details
Published in:British journal of cancer 2003-06, Vol.88 (12), p.1942-1947
Main Authors: Jamieson, S M F, Liu, J, Hsu, T, Baguley, B C, McKeage, M J
Format: Article
Language:English
Subjects:
Age Factors
Animals
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Cancer Research
Cancer therapies
Drug dosages
Drug Resistance
Drug Therapy, Combination
Drug toxicity and drugs side effects treatment
Epidemiology
Experimental Therapeutics
Female
Ganglia, Spinal - drug effects
Medical research
Medical sciences
Molecular Medicine
Nervous system
Neurotoxicity
Oncology
Organoplatinum Compounds - administration & dosage
Organoplatinum Compounds - toxicity
Oxaliplatin
Paclitaxel - administration & dosage
Paclitaxel - pharmacology
Pharmacokinetics
Pharmacology
Pharmacology. Drug treatments
Rats
Toxicity
Toxicity: nervous system and muscle
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Summary:Paclitaxel and oxaliplatin are promising drugs for combination trials but both induce peripheral neurotoxicity. To investigate this toxicity, 10-week-old female Wistar rats were given single intraperitoneal doses of paclitaxel and oxaliplatin, alone or in combination. Neurotoxicity was assessed by L5 dorsal root ganglion morphometry and H-reflex-related sensory nerve conduction velocity. Platinum concentrations in dorsal root ganglia and plasma were measured by inductively coupled plasma mass spectrometry. Dorsal root ganglion nucleolus size was significantly increased following single doses of paclitaxel of 10 and 20 mg kg −1 at 24 h and 6 days ( P
ISSN:0007-0920
1532-1827
DOI:10.1038/sj.bjc.6601012