Roles of galectins in inflammatory bowel disease

Protein/carbohydrate interactions through specific protein families termed lectin control essential biological processes. Galectins, a family of animal lectins defined by shared amino acid sequence with affinity for β-galactosides, appear to be functionally polyvalent in a wide range of biological a...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2008-09, Vol.14 (33), p.5133-5137
Main Authors: Hokama, Akira, Mizoguchi, Emiko, Mizoguchi, Atsushi
Format: Article
Language:English
Subjects:
Apoptosis - physiology
Carbohydrate Metabolism - physiology
Galectins - physiology
Humans
Inflammatory Bowel Diseases - pathology
Inflammatory Bowel Diseases - physiopathology
Signal Transduction - physiology
T-Lymphocytes - pathology
Topic Highlights
克罗恩氏病
发病机理
溃疡性结肠炎
糖基化
肠疾病
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Summary:Protein/carbohydrate interactions through specific protein families termed lectin control essential biological processes. Galectins, a family of animal lectins defined by shared amino acid sequence with affinity for β-galactosides, appear to be functionally polyvalent in a wide range of biological activity. Recent studies have identified immunoregulatory roles of galectins in intestinal inflammatory disorders. Galectin-1 and galectin -2 contribute to the suppression of intestinal inflammation by the induction of apoptosis of activated T cells, whereas galectin-4 is involved in the exacerbation of this inflammation by specifically stimulating intestinal CD4＋ T cells to produce IL-6. We review how different members of the galectins provide inhibitory or stimulatory signals to control intestinal immune response under intestinal inflammation.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.14.5133