Relapse associated with active disease caused by Beijing strain of Mycobacterium tuberculosis

The role of microbial factors in outcomes of tuberculosis treatment has not been well studied. We performed a case-control study to evaluate the association between a Beijing strain and tuberculosis treatment outcomes. Isolates from patients with culture-positive treatment failure (n = 8) or relapse...

Full description

Saved in:
Bibliographic Details
Published in:Emerging infectious diseases 2009-07, Vol.15 (7), p.1061-1067
Main Authors: Burman, William J, Bliven, Erin E, Cowan, Lauren, Bozeman, Lorna, Nahid, Payam, Diem, Lois, Vernon, Andrew
Format: Article
Language:English
Subjects:
Antibiotics, Antitubercular - therapeutic use
Antitubercular Agents - therapeutic use
Asian Continental Ancestry Group - statistics & numerical data
Beijing strain
Case-Control Studies
Causes of
China
Diagnosis
Diseases
genotyping
Health aspects
HIV Infections - complications
Humans
Mycobacterium tuberculosis
Mycobacterium tuberculosis - genetics
Mycobacterium tuberculosis - isolation & purification
Recurrence
Relapse
Rifampin - analogs & derivatives
Rifampin - therapeutic use
risk factor
Risk Factors
Treatment Failure
Treatment Outcome
Tuberculosis
Tuberculosis - drug therapy
Tuberculosis - genetics
Tuberculosis - microbiology
tuberculosis and other mycobacteria
Tuberculosis, Pulmonary - drug therapy
Tuberculosis, Pulmonary - genetics
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The role of microbial factors in outcomes of tuberculosis treatment has not been well studied. We performed a case-control study to evaluate the association between a Beijing strain and tuberculosis treatment outcomes. Isolates from patients with culture-positive treatment failure (n = 8) or relapse (n = 54) were compared with isolates from randomly selected controls (n = 296) by using spoligotyping. Patients with Beijing strains had a higher risk for relapse (odds ratio [OR] 2.0, 95% confidence interval [CI] 1.0-4.0, p = 0.04) but not for treatment failure. Adjustment for factors previously associated with relapse had little effect on the association between Beijing strains and relapse. Beijing strains were strongly associated with relapse among Asian-Pacific Islanders (OR 11, 95% CI 1.1-108, p = 0.04). Active disease caused by a Beijing strain was associated with increased risk for relapse, particularly among Asian-Pacific Islanders.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid1507.081253