Magnetic resonance imaging analysis of the bioabsorbable Milagro™ interference screw for graft fixation in anterior cruciate ligament reconstruction

Ligament graft fixation with bioabsorbable interference screws is a standard procedure in cruciate ligament replacement. Previous screw designs may resorb incompletely, and can cause osteolysis and sterile cysts despite being implanted for several years. The aim of this study was to examine the in v...

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Bibliographic Details
Published in:Strategies in trauma and limb reconstruction 2009-10, Vol.4 (2), p.73-79
Main Authors: Frosch, K.-H., Sawallich, T., Schütze, G., Losch, A., Walde, T., Balcarek, P., Konietschke, F., Stürmer, K. M.
Format: Article
Language:English
Subjects:
Anterior cruciate ligament
Biocompatibility
Bone resorption
Calcium phosphates
Edema
Enlargement
Femur
Fixation
Glycolic acid
Grafting
Grafts
In vivo methods and tests
Interference
Ligaments
Magnetic resonance imaging
Medical imaging
Medicine
Medicine & Public Health
Original
Original Article
Orthopedics
Osteoconduction
Osteolysis
Patients
Polylactide-co-glycolide
Screws
Surgical Orthopedics
Traumatic Surgery
Tricalcium phosphate
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Summary:Ligament graft fixation with bioabsorbable interference screws is a standard procedure in cruciate ligament replacement. Previous screw designs may resorb incompletely, and can cause osteolysis and sterile cysts despite being implanted for several years. The aim of this study was to examine the in vivo degradation and biocompatibility of the new Milagro™ interference screw (Mitek, Norderstedt, Germany). The Milagro™ interference screw is made of 30% ß-TCP (TriCalcium phosphate) and 70% PLGA (Poly-lactic-co-glycolic acid). In the period between June 2005 and February 2006, 38 patients underwent graft fixation with Milagro™ screws in our hospital. Arthroscopic ACL reconstruction was performed using hamstring tendon grafts in all the patients. MR imaging was performed on 12 randomly selected patients out of the total of 38 at 3, 6 and 12 months after surgery. During the examination, the volume loss of the screw, tunnel enlargement, presence of osteolysis, fluid lines, edema and postoperative screw replacement by bone tissue were evaluated. There was no edema or signs of inflammation around the bone tunnels. At 3, 6 and 12 months, the tibial screws showed an average volume loss of 0, 8.1% (±7.9%) and 82.6% (±17.2%, P  
ISSN:1828-8936
1828-8928
DOI:10.1007/s11751-009-0063-2