The effect of early pregnancy following chemotherapy on disease relapse and foetal outcome in women treated for gestational trophoblastic tumours

Little literature exists on the safety of early pregnancy following chemotherapy. Here we assess the rate of relapse and foetal outcome in women who have completed single and multi-agent chemotherapy for gestational trophoblastic tumours. The records of 1532 patients treated for persistent gestation...

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Bibliographic Details
Published in:British journal of cancer 2002-01, Vol.86 (1), p.26-30
Main Authors: Blagden, S P, Foskett, M A, Fisher, R A, Short, D, Fuller, S, Newlands, E S, Seckl, M J
Format: Article
Language:English
Subjects:
Abortion, Spontaneous - etiology
Adolescent
Adult
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Cancer Research
Chemotherapy
Clinical
Congenital Abnormalities - etiology
Diseases of mother, fetus and pregnancy
Drug Resistance
Epidemiology
Female
Fertility
Fetal Death - etiology
Gynecology. Andrology. Obstetrics
Humans
Medical research
Medical sciences
Middle Aged
Molecular Medicine
Neoplasm Recurrence, Local
Oncology
Pregnancy
Pregnancy. Fetus. Placenta
Retrospective Studies
Trophoblastic Neoplasms - complications
Trophoblastic Neoplasms - drug therapy
Tumors
Uterine Neoplasms - complications
Uterine Neoplasms - drug therapy
Womens health
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Summary:Little literature exists on the safety of early pregnancy following chemotherapy. Here we assess the rate of relapse and foetal outcome in women who have completed single and multi-agent chemotherapy for gestational trophoblastic tumours. The records of 1532 patients treated for persistent gestational trophoblastic tumours at Charing Cross Hospital between 1969 and 1998 were reviewed. Patients were defined as receiving single agent or multi-agent treatment. Relapse rates and foetal outcome were reviewed in the 230 patients who became pregnant within 12 months of completing chemotherapy. In the single agent group 153 (22%) of 691 patients conceived early. Three subsequently relapsed. In the multi-agent group, 77 (10%) of 779 patients conceived early, two then relapsed. Relapse rates were 2% (3 out of 153) and 2.5% (2 out of 77) for each group compared to 5% and 5.6% in the comparative non-pregnant groups. Outcomes of 230 early pregnancies: 164 (71%) delivered at full term, 35 (15%) terminations, 26 (11%) spontaneous abortions, three (1.3%) new hydatidiform moles and two (1%) stillbirths. Early pregnancies were more common in the single agent group ( P
ISSN:0007-0920
1532-1827
DOI:10.1038/sj.bjc.6600041