Helicobacter pylori virulence factors in gastric carcinogenesis

Abstract Helicobacter pylori infection is the most important risk factor in the development of non-cardia gastric adenocarcinoma; host genetic variability and dietary co-factors also modulate risk. Because most H. pylori infections do not cause cancer, H. pylori heterogeneity has been investigated t...

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Bibliographic Details
Published in:Cancer letters 2009-09, Vol.282 (1), p.1-8
Main Authors: Wen, Sicheng, Moss, Steven F
Format: Article
Language:English
Subjects:
Animals
Antigens, Bacterial - genetics
Antigens, Bacterial - metabolism
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
CagA
Cell culture
Cytokines
Disease
Disease Models, Animal
Gastric cancer
Gastric Mucosa - pathology
Gene Deletion
Genes
Genetic diversity
Helicobacter Infections - complications
Helicobacter pylori
Helicobacter pylori - genetics
Helicobacter pylori - pathogenicity
Hematology, Oncology and Palliative Medicine
Humans
Infections
Mortality
Pathogenesis
Phosphorylation
Polymorphism, Genetic
Proteins
Stomach Neoplasms - microbiology
Stomach Neoplasms - pathology
Stomach Neoplasms - prevention & control
Ulcers
VacA
Virulence
Virulence factors
Virulence Factors - genetics
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Summary:Abstract Helicobacter pylori infection is the most important risk factor in the development of non-cardia gastric adenocarcinoma; host genetic variability and dietary co-factors also modulate risk. Because most H. pylori infections do not cause cancer, H. pylori heterogeneity has been investigated to identify possible virulence factors. The strongest candidates are genes within the cag (cytotoxin-associated antigen) pathogenicity island, including the gene encoding the CagA protein, as well as polymorphic variation in the VacA vacuolating exotoxin and the blood group antigen binding adhesin BabA. Improved understanding of the pathogenesis of H. pylori -associated gastric cancer may improve risk stratification for prevention and therapy.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2008.11.016