General and Efficient Method for the Suzuki-Miyaura Coupling of 2-Pyridyl Nucleophiles

One of the most general systems for the cross‐coupling of aryl and heteroaryl bromides and chlorides with 2‐pyridyl‐derived nucleophiles has been developed, for which catalysts comprising [Pd2(dba)3] and either diaryl (1) or dialkyl phosphine oxide (2) supporting ligands were found to be ideal (see...

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Bibliographic Details
Published in:Angewandte Chemie (International ed.) 2008-01, Vol.47 (25), p.4695-4698
Main Authors: Billingsley, Kelvin L, Buchwald, Stephen L
Format: Article
Language:English
Subjects:
Borates - chemistry
CC coupling
Heterocyclic Compounds - chemistry
Ligands
Molecular Structure
nitrogen heterocycles
palladium
Palladium - chemistry
Pyridines - chemistry
Suzuki-Miyaura coupling
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Summary:One of the most general systems for the cross‐coupling of aryl and heteroaryl bromides and chlorides with 2‐pyridyl‐derived nucleophiles has been developed, for which catalysts comprising [Pd2(dba)3] and either diaryl (1) or dialkyl phosphine oxide (2) supporting ligands were found to be ideal (see scheme).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200801465