The Pharmacokinetics and Interactions of Ivermectin in Humans—A Mini-review

Ivermectin is an antiparasitic drug with a broad spectrum of activity, high efficacy as well as a wide margin of safety. Since 1987, this compound has a widespread use in veterinary medicine and it use has been extended in humans. Here we present a brief review of the information availabile regardin...

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Bibliographic Details
Published in:The AAPS journal 2008, Vol.10 (1), p.42-46
Main Authors: González Canga, Aránzazu, Sahagún Prieto, Ana M., Diez Liébana, M. José, Fernández Martínez, Nélida, Sierra Vega, Matilde, García Vieitez, Juan J.
Format: Article
Language:English
Subjects:
Animals
Antiparasitic Agents - metabolism
Antiparasitic Agents - pharmacokinetics
Antiparasitic Agents - therapeutic use
Biochemistry
Biomedical and Life Sciences
Biomedicine
Biotechnology
Drug Interactions - physiology
Food-Drug Interactions - physiology
Humans
Ivermectin - metabolism
Ivermectin - pharmacokinetics
Ivermectin - therapeutic use
Mini-Review
Parasitic Diseases - drug therapy
Parasitic Diseases - metabolism
Pharmacology/Toxicology
Pharmacy
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Summary:Ivermectin is an antiparasitic drug with a broad spectrum of activity, high efficacy as well as a wide margin of safety. Since 1987, this compound has a widespread use in veterinary medicine and it use has been extended in humans. Here we present a brief review of the information availabile regarding the pharmacokinetics and interactions of ivermectin in humans. Awareness of these characteristics could improve the clinical efficacy of Ivermectin. All Authors declare that they do not have any Conflict of interest and that the work is original. All Authors agree that the contents of the manuscript are confidential and will not be copyrighted, submitted, or published elsewhere (including the Internet), in any language, while acceptance by the Journal is under consideration.
ISSN:1550-7416
1550-7416
DOI:10.1208/s12248-007-9000-9