Thin-film enhanced nerve guidance channels for peripheral nerve repair

Abstract It has been demonstrated that nerve guidance channels containing stacked thin-films of aligned poly(acrylonitrile- co -methylacrylate) fibers support peripheral nerve regeneration across critical sized nerve gaps, without the aid of exogenous cells or proteins. Here, we explore the ability...

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Bibliographic Details
Published in:Biomaterials 2009-08, Vol.30 (23), p.3834-3846
Main Authors: Clements, Isaac P, Kim, Young-tae, English, Arthur W, Lu, Xi, Chung, Andy, Bellamkonda, Ravi V
Format: Article
Language:English
Subjects:
Advanced Basic Science
Animals
Biocompatible Materials - chemistry
Contact guidance
Dentistry
Electromyography
Electrophysiology
Electrospinning
Guided Tissue Regeneration - methods
Immunohistochemistry
Nerve guide
Nerve regeneration
Nerve Regeneration - physiology
Peripheral Nerves - surgery
Rats
Rats, Inbred F344
Thin-films
Tissue Engineering
Topography
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Summary:Abstract It has been demonstrated that nerve guidance channels containing stacked thin-films of aligned poly(acrylonitrile- co -methylacrylate) fibers support peripheral nerve regeneration across critical sized nerve gaps, without the aid of exogenous cells or proteins. Here, we explore the ability of tubular channels minimally supplemented with aligned nanofiber-based thin-films to promote endogenous nerve repair. We describe a technique for fabricating guidance channels in which individual thin-films are fixed into place within the lumen of a polysulfone tube. Because each thin-film is
ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2009.04.022