A systematic review of treating Helicobacter pylori infection with Traditional Chinese Medicine

To evaluate the efficacy and safety of Traditional Chinese Medicine (TCM) in the treatment of Helicobacter pylori (H. pylori) infection. We electronically and manually searched electronic databases, references lists and conferences compilations, and included all randomized clinical trials comparing...

Full description

Saved in:
Bibliographic Details
Published in:World journal of gastroenterology : WJG 2009-10, Vol.15 (37), p.4715-4719
Main Authors: Lin, Jiang, Huang, Wei-Wen
Format: Article
Language:English
Subjects:
Brief
Drug Therapy, Combination
Drugs, Chinese Herbal - adverse effects
Drugs, Chinese Herbal - therapeutic use
Helicobacter Infections - drug therapy
Helicobacter pylori - drug effects
Humans
Medicine, Chinese Traditional - adverse effects
Organometallic Compounds - therapeutic use
Phytotherapy
Proton Pump Inhibitors - therapeutic use
Randomized Controlled Trials as Topic
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To evaluate the efficacy and safety of Traditional Chinese Medicine (TCM) in the treatment of Helicobacter pylori (H. pylori) infection. We electronically and manually searched electronic databases, references lists and conferences compilations, and included all randomized clinical trials comparing the treatment of H. pylori using TCM with proton pump inhibitor or colloidal bismuth subcitrate-based triple therapy as controls. The Jadad score was used to assess trial quality, H. pylori eradication rate and the incidence of side effects were taken as outcome measurements, and heterogeneity analysis, meta-analysis and funnel plot analysis were conducted. Sixteen trials were included. The Jadad scores of all the trials were not more than 2. Clinical heterogeneity and substantial statistical heterogeneity existed among the trials (P = 0.001, I(2) = 59%) and meta-analysis was not conducted. The average eradication rates following TCM and triple therapy were 72% and 78% and the incidence of side effects were 2% and 29%, respectively. The funnel plot was obviously asymmetric. Available evidence is not convincing enough to show that TCM has the same efficacy as triple therapy in H. pylori treatment. TCM may be safer than triple therapy. TCM should not be recommended as monotherapy in H. pylori infection.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.15.4715