Formation and properties of magnetic chains for 100 nm nanoparticles used in separations of molecules and cells

Optical observations of 100 nm metallic magnetic nanoparticles are used to study their magnetic field induced self assembly. Chains with lengths of tens of microns are observed to form within minutes at nanoparticle concentrations 10 10/mL. Chain rotation and magnetophoresis are readily observed, an...

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Bibliographic Details
Published in:Journal of magnetism and magnetic materials 2009-05, Vol.321 (10), p.1452-1458
Main Authors: Wilson, Robert J., Hu, Wei, Fu, Cheryl Wong Po, Koh, Ai Leen, Gaster, Richard S., Earhart, Christopher M., Fu, Aihua, Heilshorn, Sarah C., Sinclair, Robert, Wang, Shan X.
Format: Article
Language:English
Subjects:
Bimetallic nanoparticle
Biological and medical sciences
Biomedical application
Cross-disciplinary physics: materials science
rheology
Exact sciences and technology
Magnetic nanoparticle
Magnetic property
Materials science
Medical sciences
Methods of nanofabrication
Nanoparticle characterization
Physics
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Self-assembly
Technology. Biomaterials. Equipments. Material. Instrumentation
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Summary:Optical observations of 100 nm metallic magnetic nanoparticles are used to study their magnetic field induced self assembly. Chains with lengths of tens of microns are observed to form within minutes at nanoparticle concentrations 10 10/mL. Chain rotation and magnetophoresis are readily observed, and SEM reveals that long chains are not simple single particle filaments. Similar chains are detected for several 100 nm commercial bio-separation nanoparticles. We demonstrate the staged magnetic condensation of different types of nanoparticles into composite structures and show that magnetic chains bind to immuno-magnetically labeled cells, serving as temporary handles which allow novel magnetic cell manipulations.
ISSN:0304-8853
DOI:10.1016/j.jmmm.2009.02.066