Early abstinence in cocaine pharmacotherapy trials predicts successful treatment outcomes

Abstract There is a robust relationship between early and later abstinence in smoking cessation, but that relationship has not been explored among other substances of abuse. To assess whether early abstinence during treatment, as opposed to baseline abstinence, predicted later abstinence among cocai...

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Bibliographic Details
Published in:Journal of substance abuse treatment 2009-10, Vol.37 (3), p.313-317
Main Authors: Plebani, Jennifer G., Ph.D, Kampman, Kyle M., M.D, Lynch, Kevin G., Ph.D
Format: Article
Language:English
Subjects:
Abstinence
Biological and medical sciences
Cessation
Clinical outcomes
Clinical trials
Cocaine
Cocaine-Related Disorders - drug therapy
Cocaine-Related Disorders - rehabilitation
Desintoxication. Drug withdrawal
Double-Blind Method
Drug addictions
Drug therapy
Female
Humans
Male
Medical sciences
Miscellaneous
Pharmacology
Pharmacotherapy
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Public health. Hygiene
Public health. Hygiene-occupational medicine
Randomized Controlled Trials as Topic
Secondary Prevention
Smoking
Smoking cessation
Smoking Cessation - methods
Substance abuse
Substance abuse treatment
Time Factors
Toxicology
Treatment Outcome
Treatments
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Summary:Abstract There is a robust relationship between early and later abstinence in smoking cessation, but that relationship has not been explored among other substances of abuse. To assess whether early abstinence during treatment, as opposed to baseline abstinence, predicted later abstinence among cocaine-dependent patients, data from two randomized double-blind controlled clinical pharmacotherapy trials were analyzed. Similar to the findings in the smoking cessation literature, results indicate that abstinence in the first 2 weeks of pharmacotherapy predicted later in-trial abstinence. This finding has implications both for treatment research and for clinical practice, suggesting that patients who do not respond early in treatment may need a more intensive intervention.
ISSN:0740-5472
1873-6483
DOI:10.1016/j.jsat.2009.02.001