Rare presentation of Kyrle's disease in siblings

Kyrle's disease is a rare variant of primary perforating dermatosis. Its occurrence in a familial setting, especially in children, is extremely uncommon. Similar appearing skin lesions have been described in adults, secondary to metabolic disorders, infective agents as well as exposure to chemi...

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Bibliographic Details
Published in:Indian journal of dermatology 2008-04, Vol.53 (2), p.85-87
Main Authors: Viswanathan, Seethalakshmi, Narurkar, Swati D, Rajpal, Aruna, Nagpur, N G, Avasare, S S
Format: Article
Language:English
Subjects:
Case Report
Case studies
Children
Diagnosis
Diseases
Risk factors
Siblings
Skin diseases
Online Access:Get full text
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Summary:Kyrle's disease is a rare variant of primary perforating dermatosis. Its occurrence in a familial setting, especially in children, is extremely uncommon. Similar appearing skin lesions have been described in adults, secondary to metabolic disorders, infective agents as well as exposure to chemicals. We present a rare case of this genodermatosis in two siblings. Two siblings of a non-consanguineous marriage came with generalized discrete papular lesions with a central keratotic plug. All biochemical and serological investigations were within normal limits. Serial sections of the biopsy revealed typical epidermal invaginations filled with parakeratotic debris and perforation into the dermis with accompanying granulomatous reaction. A careful history, detailed routine investigations and serial sections of the skin biopsy are required to demonstrate the typical morphology and stages of evolution of Kyrle's disease. This helps to differentiate the rare primary Kyrle's disease from other primary and secondary keratotic lesions. Due to the familial occurrence, screening of relatives of an index case is recommended.
ISSN:0019-5154
1998-3611
DOI:10.4103/0019-5154.41654