Observations in the synthesis of the core of the antitumor illudins via an enyne ring closing metathesis cascade

Observations related to the synthesis of the functional spirocyclic AB-ring system found in a variety of illudins via a key enyne ring closing metathesis cascade are described. Observations concerning the synthesis of the core spirocyclic AB-ring system of illudins using an enyne ring closing metath...

Full description

Saved in:
Bibliographic Details
Published in:Tetrahedron letters 2009-09, Vol.50 (39), p.5489-5492
Main Authors: Movassaghi, Mohammad, Piizzi, Grazia, Siegel, Dustin S., Piersanti, Giovanni
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Observations related to the synthesis of the functional spirocyclic AB-ring system found in a variety of illudins via a key enyne ring closing metathesis cascade are described. Observations concerning the synthesis of the core spirocyclic AB-ring system of illudins using an enyne ring closing metathesis (EYRCM) cascade are discussed. Substituent effects, in addition to optimization of the reaction conditions and the olefin tether for the key EYRCM reaction, are examined.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2009.07.102