Spatial Patterns in Discordant Diagnostic Test Results for Chagas Disease: Links to Transmission Hotspots

Diagnosis of Chagas disease is hindered by discordance between screening and confirmatory test results for Trypanosoma cruzi infection. In periurban Arequipa, Peru, spatial analysis revealed that individuals with discordant test results are spatially clustered in hotspots of T. cruzi transmission, s...

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Bibliographic Details
Published in:Clinical infectious diseases 2009-04, Vol.48 (8), p.1104-1106
Main Authors: Levy, Michael Z., Bowman, Natalie M., Kawai, Vivian, Plotkin, Joshua B., Waller, Lance A., Cabrera, Lilia, Steurer, Frank, Seitz, Amy E., Cancino, Viviana V. Pinedo, Cornejo del Carpio, Juan Geny, Benzaquen, Eleazar Cordova, McKenzie, F. Ellis, Maguire, James H., Gilman, Robert H., Bern, Caryn
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Brief Reports
Chagas disease
Chagas Disease - diagnosis
Chagas Disease - epidemiology
Chagas Disease - transmission
Children
Cluster Analysis
Communities
Computer Simulation
Disease transmission
Enzyme-Linked Immunosorbent Assay
Fluorescent Antibody Technique
Human protozoal diseases
Humans
Infections
Infectious diseases
Medical diagnosis
Medical diagnostic tests
Medical sciences
Medical screening
Models, Biological
Monte Carlo Method
Null hypothesis
Parasitic diseases
Peru - epidemiology
Protozoal diseases
Radioimmunoprecipitation Assay
Screening tests
Statistics
Time Factors
Topography, Medical
Trypanosoma cruzi
Trypanosoma cruzi - isolation & purification
Trypanosomiasis
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Summary:Diagnosis of Chagas disease is hindered by discordance between screening and confirmatory test results for Trypanosoma cruzi infection. In periurban Arequipa, Peru, spatial analysis revealed that individuals with discordant test results are spatially clustered in hotspots of T. cruzi transmission, suggesting that discordant results likely represent true infections in this setting.
ISSN:1058-4838
1537-6591
DOI:10.1086/597464