Loading…

Spatial Patterns in Discordant Diagnostic Test Results for Chagas Disease: Links to Transmission Hotspots

Diagnosis of Chagas disease is hindered by discordance between screening and confirmatory test results for Trypanosoma cruzi infection. In periurban Arequipa, Peru, spatial analysis revealed that individuals with discordant test results are spatially clustered in hotspots of T. cruzi transmission, s...

Full description

Saved in:
Bibliographic Details
Published in:Clinical infectious diseases 2009-04, Vol.48 (8), p.1104-1106
Main Authors: Levy, Michael Z., Bowman, Natalie M., Kawai, Vivian, Plotkin, Joshua B., Waller, Lance A., Cabrera, Lilia, Steurer, Frank, Seitz, Amy E., Cancino, Viviana V. Pinedo, Cornejo del Carpio, Juan Geny, Benzaquen, Eleazar Cordova, McKenzie, F. Ellis, Maguire, James H., Gilman, Robert H., Bern, Caryn
Format: Article
Language:English
Subjects:
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c539t-c5887b76fe3a0b43464822000eab368bb5595ad6361717f3479443a37302cf2f3
cites
container_end_page 1106
container_issue 8
container_start_page 1104
container_title Clinical infectious diseases
container_volume 48
creator Levy, Michael Z.
Bowman, Natalie M.
Kawai, Vivian
Plotkin, Joshua B.
Waller, Lance A.
Cabrera, Lilia
Steurer, Frank
Seitz, Amy E.
Cancino, Viviana V. Pinedo
Cornejo del Carpio, Juan Geny
Benzaquen, Eleazar Cordova
McKenzie, F. Ellis
Maguire, James H.
Gilman, Robert H.
Bern, Caryn
description Diagnosis of Chagas disease is hindered by discordance between screening and confirmatory test results for Trypanosoma cruzi infection. In periurban Arequipa, Peru, spatial analysis revealed that individuals with discordant test results are spatially clustered in hotspots of T. cruzi transmission, suggesting that discordant results likely represent true infections in this setting.
doi_str_mv 10.1086/597464
format article
fullrecord <record><control><sourceid>jstor_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2766414</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>40308967</jstor_id><oup_id>10.1086/597464</oup_id><sourcerecordid>40308967</sourcerecordid><originalsourceid>FETCH-LOGICAL-c539t-c5887b76fe3a0b43464822000eab368bb5595ad6361717f3479443a37302cf2f3</originalsourceid><addsrcrecordid>eNp9kV2LEzEUhgdR3HXVf6BkBfWqmszJ13ghSP2oUHTRCuJNyEwzu-lOk5qTEf33prZ0VdCLJAfOw3vynreq7jL6hFEtn4pGccmvVcdMgJpI0bDrpaZCT7gGfVTdQlxRypim4mZ1xJpaaQBxXPmPG5u9HciZzdmlgMQH8tJjF9PShlxKex4iZt-RhcNMPjgch4ykj4lML-y5xS3tLLpnZO7DJZIcySLZgGuP6GMgs5hxU87t6kZvB3R39u9J9en1q8V0Npm_f_N2-mI-6QQ0udxaq1bJ3oGlLYfiStc1pdTZFqRuWyEaYZcSJFNM9cBVwzlYUEDrrq97OKme73Q3Y7t2y86FnOxgNsmvbfphovXmz07wF-Y8fjO1kpIzXgQe7wVS_DoW06ZY6dww2ODiiEYJwThTUhXy0X9JqShoELqAD_4CV3FMoazB1KxphJLAr9S6FBGT6w9_ZtRsQza7kAt4_3eHV9g-1QI83AMWOzv0JY7O44GrGdRc8K3Q6Y6L4-bfw-7tmBXmmA4Up0B182sHk13fY3bfD32bLot9UMLMPn8xgp4JBsDNO_gJKx7QNA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>219957634</pqid></control><display><type>article</type><title>Spatial Patterns in Discordant Diagnostic Test Results for Chagas Disease: Links to Transmission Hotspots</title><source>JSTOR Archival Journals and Primary Sources Collection</source><source>Oxford Journals Online</source><creator>Levy, Michael Z. ; Bowman, Natalie M. ; Kawai, Vivian ; Plotkin, Joshua B. ; Waller, Lance A. ; Cabrera, Lilia ; Steurer, Frank ; Seitz, Amy E. ; Cancino, Viviana V. Pinedo ; Cornejo del Carpio, Juan Geny ; Benzaquen, Eleazar Cordova ; McKenzie, F. Ellis ; Maguire, James H. ; Gilman, Robert H. ; Bern, Caryn</creator><creatorcontrib>Levy, Michael Z. ; Bowman, Natalie M. ; Kawai, Vivian ; Plotkin, Joshua B. ; Waller, Lance A. ; Cabrera, Lilia ; Steurer, Frank ; Seitz, Amy E. ; Cancino, Viviana V. Pinedo ; Cornejo del Carpio, Juan Geny ; Benzaquen, Eleazar Cordova ; McKenzie, F. Ellis ; Maguire, James H. ; Gilman, Robert H. ; Bern, Caryn</creatorcontrib><description>Diagnosis of Chagas disease is hindered by discordance between screening and confirmatory test results for Trypanosoma cruzi infection. In periurban Arequipa, Peru, spatial analysis revealed that individuals with discordant test results are spatially clustered in hotspots of T. cruzi transmission, suggesting that discordant results likely represent true infections in this setting.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1086/597464</identifier><identifier>PMID: 19278335</identifier><identifier>CODEN: CIDIEL</identifier><language>eng</language><publisher>Oxford: The University of Chicago Press</publisher><subject>Animals ; Biological and medical sciences ; Brief Reports ; Chagas disease ; Chagas Disease - diagnosis ; Chagas Disease - epidemiology ; Chagas Disease - transmission ; Children ; Cluster Analysis ; Communities ; Computer Simulation ; Disease transmission ; Enzyme-Linked Immunosorbent Assay ; Fluorescent Antibody Technique ; Human protozoal diseases ; Humans ; Infections ; Infectious diseases ; Medical diagnosis ; Medical diagnostic tests ; Medical sciences ; Medical screening ; Models, Biological ; Monte Carlo Method ; Null hypothesis ; Parasitic diseases ; Peru - epidemiology ; Protozoal diseases ; Radioimmunoprecipitation Assay ; Screening tests ; Statistics ; Time Factors ; Topography, Medical ; Trypanosoma cruzi ; Trypanosoma cruzi - isolation &amp; purification ; Trypanosomiasis</subject><ispartof>Clinical infectious diseases, 2009-04, Vol.48 (8), p.1104-1106</ispartof><rights>Copyright 2008 Infectious Diseases Society of America</rights><rights>2009 by the Infectious Diseases Society of America 2009</rights><rights>2009 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Apr 15, 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c539t-c5887b76fe3a0b43464822000eab368bb5595ad6361717f3479443a37302cf2f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/40308967$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/40308967$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,58238,58471</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=21324544$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19278335$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Levy, Michael Z.</creatorcontrib><creatorcontrib>Bowman, Natalie M.</creatorcontrib><creatorcontrib>Kawai, Vivian</creatorcontrib><creatorcontrib>Plotkin, Joshua B.</creatorcontrib><creatorcontrib>Waller, Lance A.</creatorcontrib><creatorcontrib>Cabrera, Lilia</creatorcontrib><creatorcontrib>Steurer, Frank</creatorcontrib><creatorcontrib>Seitz, Amy E.</creatorcontrib><creatorcontrib>Cancino, Viviana V. Pinedo</creatorcontrib><creatorcontrib>Cornejo del Carpio, Juan Geny</creatorcontrib><creatorcontrib>Benzaquen, Eleazar Cordova</creatorcontrib><creatorcontrib>McKenzie, F. Ellis</creatorcontrib><creatorcontrib>Maguire, James H.</creatorcontrib><creatorcontrib>Gilman, Robert H.</creatorcontrib><creatorcontrib>Bern, Caryn</creatorcontrib><title>Spatial Patterns in Discordant Diagnostic Test Results for Chagas Disease: Links to Transmission Hotspots</title><title>Clinical infectious diseases</title><addtitle>Clinical Infectious Diseases</addtitle><addtitle>Clinical Infectious Diseases</addtitle><description>Diagnosis of Chagas disease is hindered by discordance between screening and confirmatory test results for Trypanosoma cruzi infection. In periurban Arequipa, Peru, spatial analysis revealed that individuals with discordant test results are spatially clustered in hotspots of T. cruzi transmission, suggesting that discordant results likely represent true infections in this setting.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brief Reports</subject><subject>Chagas disease</subject><subject>Chagas Disease - diagnosis</subject><subject>Chagas Disease - epidemiology</subject><subject>Chagas Disease - transmission</subject><subject>Children</subject><subject>Cluster Analysis</subject><subject>Communities</subject><subject>Computer Simulation</subject><subject>Disease transmission</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Fluorescent Antibody Technique</subject><subject>Human protozoal diseases</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Medical diagnosis</subject><subject>Medical diagnostic tests</subject><subject>Medical sciences</subject><subject>Medical screening</subject><subject>Models, Biological</subject><subject>Monte Carlo Method</subject><subject>Null hypothesis</subject><subject>Parasitic diseases</subject><subject>Peru - epidemiology</subject><subject>Protozoal diseases</subject><subject>Radioimmunoprecipitation Assay</subject><subject>Screening tests</subject><subject>Statistics</subject><subject>Time Factors</subject><subject>Topography, Medical</subject><subject>Trypanosoma cruzi</subject><subject>Trypanosoma cruzi - isolation &amp; purification</subject><subject>Trypanosomiasis</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNp9kV2LEzEUhgdR3HXVf6BkBfWqmszJ13ghSP2oUHTRCuJNyEwzu-lOk5qTEf33prZ0VdCLJAfOw3vynreq7jL6hFEtn4pGccmvVcdMgJpI0bDrpaZCT7gGfVTdQlxRypim4mZ1xJpaaQBxXPmPG5u9HciZzdmlgMQH8tJjF9PShlxKex4iZt-RhcNMPjgch4ykj4lML-y5xS3tLLpnZO7DJZIcySLZgGuP6GMgs5hxU87t6kZvB3R39u9J9en1q8V0Npm_f_N2-mI-6QQ0udxaq1bJ3oGlLYfiStc1pdTZFqRuWyEaYZcSJFNM9cBVwzlYUEDrrq97OKme73Q3Y7t2y86FnOxgNsmvbfphovXmz07wF-Y8fjO1kpIzXgQe7wVS_DoW06ZY6dww2ODiiEYJwThTUhXy0X9JqShoELqAD_4CV3FMoazB1KxphJLAr9S6FBGT6w9_ZtRsQza7kAt4_3eHV9g-1QI83AMWOzv0JY7O44GrGdRc8K3Q6Y6L4-bfw-7tmBXmmA4Up0B182sHk13fY3bfD32bLot9UMLMPn8xgp4JBsDNO_gJKx7QNA</recordid><startdate>20090415</startdate><enddate>20090415</enddate><creator>Levy, Michael Z.</creator><creator>Bowman, Natalie M.</creator><creator>Kawai, Vivian</creator><creator>Plotkin, Joshua B.</creator><creator>Waller, Lance A.</creator><creator>Cabrera, Lilia</creator><creator>Steurer, Frank</creator><creator>Seitz, Amy E.</creator><creator>Cancino, Viviana V. Pinedo</creator><creator>Cornejo del Carpio, Juan Geny</creator><creator>Benzaquen, Eleazar Cordova</creator><creator>McKenzie, F. Ellis</creator><creator>Maguire, James H.</creator><creator>Gilman, Robert H.</creator><creator>Bern, Caryn</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T2</scope><scope>7T7</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090415</creationdate><title>Spatial Patterns in Discordant Diagnostic Test Results for Chagas Disease: Links to Transmission Hotspots</title><author>Levy, Michael Z. ; Bowman, Natalie M. ; Kawai, Vivian ; Plotkin, Joshua B. ; Waller, Lance A. ; Cabrera, Lilia ; Steurer, Frank ; Seitz, Amy E. ; Cancino, Viviana V. Pinedo ; Cornejo del Carpio, Juan Geny ; Benzaquen, Eleazar Cordova ; McKenzie, F. Ellis ; Maguire, James H. ; Gilman, Robert H. ; Bern, Caryn</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c539t-c5887b76fe3a0b43464822000eab368bb5595ad6361717f3479443a37302cf2f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brief Reports</topic><topic>Chagas disease</topic><topic>Chagas Disease - diagnosis</topic><topic>Chagas Disease - epidemiology</topic><topic>Chagas Disease - transmission</topic><topic>Children</topic><topic>Cluster Analysis</topic><topic>Communities</topic><topic>Computer Simulation</topic><topic>Disease transmission</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Fluorescent Antibody Technique</topic><topic>Human protozoal diseases</topic><topic>Humans</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Medical diagnosis</topic><topic>Medical diagnostic tests</topic><topic>Medical sciences</topic><topic>Medical screening</topic><topic>Models, Biological</topic><topic>Monte Carlo Method</topic><topic>Null hypothesis</topic><topic>Parasitic diseases</topic><topic>Peru - epidemiology</topic><topic>Protozoal diseases</topic><topic>Radioimmunoprecipitation Assay</topic><topic>Screening tests</topic><topic>Statistics</topic><topic>Time Factors</topic><topic>Topography, Medical</topic><topic>Trypanosoma cruzi</topic><topic>Trypanosoma cruzi - isolation &amp; purification</topic><topic>Trypanosomiasis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Levy, Michael Z.</creatorcontrib><creatorcontrib>Bowman, Natalie M.</creatorcontrib><creatorcontrib>Kawai, Vivian</creatorcontrib><creatorcontrib>Plotkin, Joshua B.</creatorcontrib><creatorcontrib>Waller, Lance A.</creatorcontrib><creatorcontrib>Cabrera, Lilia</creatorcontrib><creatorcontrib>Steurer, Frank</creatorcontrib><creatorcontrib>Seitz, Amy E.</creatorcontrib><creatorcontrib>Cancino, Viviana V. Pinedo</creatorcontrib><creatorcontrib>Cornejo del Carpio, Juan Geny</creatorcontrib><creatorcontrib>Benzaquen, Eleazar Cordova</creatorcontrib><creatorcontrib>McKenzie, F. Ellis</creatorcontrib><creatorcontrib>Maguire, James H.</creatorcontrib><creatorcontrib>Gilman, Robert H.</creatorcontrib><creatorcontrib>Bern, Caryn</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Levy, Michael Z.</au><au>Bowman, Natalie M.</au><au>Kawai, Vivian</au><au>Plotkin, Joshua B.</au><au>Waller, Lance A.</au><au>Cabrera, Lilia</au><au>Steurer, Frank</au><au>Seitz, Amy E.</au><au>Cancino, Viviana V. Pinedo</au><au>Cornejo del Carpio, Juan Geny</au><au>Benzaquen, Eleazar Cordova</au><au>McKenzie, F. Ellis</au><au>Maguire, James H.</au><au>Gilman, Robert H.</au><au>Bern, Caryn</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spatial Patterns in Discordant Diagnostic Test Results for Chagas Disease: Links to Transmission Hotspots</atitle><jtitle>Clinical infectious diseases</jtitle><stitle>Clinical Infectious Diseases</stitle><addtitle>Clinical Infectious Diseases</addtitle><date>2009-04-15</date><risdate>2009</risdate><volume>48</volume><issue>8</issue><spage>1104</spage><epage>1106</epage><pages>1104-1106</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><coden>CIDIEL</coden><abstract>Diagnosis of Chagas disease is hindered by discordance between screening and confirmatory test results for Trypanosoma cruzi infection. In periurban Arequipa, Peru, spatial analysis revealed that individuals with discordant test results are spatially clustered in hotspots of T. cruzi transmission, suggesting that discordant results likely represent true infections in this setting.</abstract><cop>Oxford</cop><pub>The University of Chicago Press</pub><pmid>19278335</pmid><doi>10.1086/597464</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1058-4838
ispartof Clinical infectious diseases, 2009-04, Vol.48 (8), p.1104-1106
issn 1058-4838
1537-6591
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2766414
source JSTOR Archival Journals and Primary Sources Collection; Oxford Journals Online
subjects Animals
Biological and medical sciences
Brief Reports
Chagas disease
Chagas Disease - diagnosis
Chagas Disease - epidemiology
Chagas Disease - transmission
Children
Cluster Analysis
Communities
Computer Simulation
Disease transmission
Enzyme-Linked Immunosorbent Assay
Fluorescent Antibody Technique
Human protozoal diseases
Humans
Infections
Infectious diseases
Medical diagnosis
Medical diagnostic tests
Medical sciences
Medical screening
Models, Biological
Monte Carlo Method
Null hypothesis
Parasitic diseases
Peru - epidemiology
Protozoal diseases
Radioimmunoprecipitation Assay
Screening tests
Statistics
Time Factors
Topography, Medical
Trypanosoma cruzi
Trypanosoma cruzi - isolation & purification
Trypanosomiasis
title Spatial Patterns in Discordant Diagnostic Test Results for Chagas Disease: Links to Transmission Hotspots
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T10%3A03%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Spatial%20Patterns%20in%20Discordant%20Diagnostic%20Test%20Results%20for%20Chagas%20Disease:%20Links%20to%20Transmission%20Hotspots&rft.jtitle=Clinical%20infectious%20diseases&rft.au=Levy,%20Michael%20Z.&rft.date=2009-04-15&rft.volume=48&rft.issue=8&rft.spage=1104&rft.epage=1106&rft.pages=1104-1106&rft.issn=1058-4838&rft.eissn=1537-6591&rft.coden=CIDIEL&rft_id=info:doi/10.1086/597464&rft_dat=%3Cjstor_pubme%3E40308967%3C/jstor_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c539t-c5887b76fe3a0b43464822000eab368bb5595ad6361717f3479443a37302cf2f3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=219957634&rft_id=info:pmid/19278335&rft_jstor_id=40308967&rft_oup_id=10.1086/597464&rfr_iscdi=true