Malaria tolerance – for whom the cell tolls?

How is it that individuals exposed to intense malaria transmission can tolerate the presence of malaria parasites in their blood at levels that would produce fever in others? In light of evidence discounting a role for nitric oxide or antibodies to plasmodial glycosylphosphatidylinositols in maintai...

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Bibliographic Details
Published in:Trends in parasitology 2006-08, Vol.22 (8), p.371-377
Main Authors: Boutlis, Craig S., Yeo, Tsin W., Anstey, Nicholas M.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Human protozoal diseases
Humans
Immune Tolerance
Immunity, Innate
Immunoparasitology Series
Infectious diseases
Malaria
Malaria - immunology
Malaria - parasitology
Medical sciences
Nitric Oxide - metabolism
Parasitemia - immunology
Parasitemia - parasitology
Parasitic diseases
Protozoal diseases
Species Specificity
Toll-Like Receptors - immunology
Toll-Like Receptors - metabolism
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Summary:How is it that individuals exposed to intense malaria transmission can tolerate the presence of malaria parasites in their blood at levels that would produce fever in others? In light of evidence discounting a role for nitric oxide or antibodies to plasmodial glycosylphosphatidylinositols in maintaining this tolerant state, refractoriness to toxin-induced Toll-like receptor-mediated signalling has emerged as a likely explanation that links malarial and bacterial endotoxin tolerance. Understanding the mechanisms underlying tolerance and the potential for cross-tolerization has significant implications for understanding the potential for antitoxic vaccine strategies, as well as interactions between different malaria species and between malaria and other human parasites.
ISSN:1471-4922
1471-5007
DOI:10.1016/j.pt.2006.06.002