Control of Stem Cell Fate by Physical Interactions with the Extracellular Matrix

A diverse array of environmental factors contributes to the overall control of stem cell activity. In particular, new data continue to mount on the influence of the extracellular matrix (ECM) on stem cell fate through physical interactions with cells, such as the control of cell geometry, ECM geomet...

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Bibliographic Details
Published in:Cell stem cell 2009-07, Vol.5 (1), p.17-26
Main Authors: Guilak, Farshid, Cohen, Daniel M., Estes, Bradley T., Gimble, Jeffrey M., Liedtke, Wolfgang, Chen, Christopher S.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cell Differentiation
Cell differentiation, maturation, development, hematopoiesis
Cell physiology
Cell Shape
Extracellular Matrix - metabolism
Extracellular Matrix - physiology
Fundamental and applied biological sciences. Psychology
Molecular and cellular biology
Regenerative Medicine
Signal Transduction
Stem Cells - cytology
Stem Cells - metabolism
Stem Cells - physiology
Tissue Engineering
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Summary:A diverse array of environmental factors contributes to the overall control of stem cell activity. In particular, new data continue to mount on the influence of the extracellular matrix (ECM) on stem cell fate through physical interactions with cells, such as the control of cell geometry, ECM geometry/topography at the nanoscale, ECM mechanical properties, and the transmission of mechanical or other biophysical factors to the cell. Here, we review some of the physical processes by which cues from the ECM can influence stem cell fate, with particular relevance to the use of stem cells in tissue engineering and regenerative medicine.
ISSN:1934-5909
1875-9777
DOI:10.1016/j.stem.2009.06.016