Understanding the Words of Chromatin Regulation

Recent studies indicate that chromatin regulatory complexes produce biological specificity in the way that letters produce meanings by combinations into words. Combinatorial assembly of chromatin regulatory complexes may be critical for maximizing the information content provided by arrays of histon...

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Bibliographic Details
Published in:Cell 2009-01, Vol.136 (2), p.200-206
Main Authors: Wu, Jiang I., Lessard, Julie, Crabtree, Gerald R.
Format: Article
Language:English
Subjects:
Animals
Chromatin Assembly and Disassembly
Chromosomal Proteins, Non-Histone - metabolism
Gene Expression Regulation
Histone Code
Humans
Vertebrates - genetics
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Description
Summary:Recent studies indicate that chromatin regulatory complexes produce biological specificity in the way that letters produce meanings by combinations into words. Combinatorial assembly of chromatin regulatory complexes may be critical for maximizing the information content provided by arrays of histone modifications.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2009.01.009