Catch-up growth in childhood and death from coronary heart disease: longitudinal study

Abstract Objective: To examine whether catch-up growth during childhood modifies the increased risk of death from coronary heart disease that is associated with reduced intrauterine growth. Design: Follow up study of men whose body size at birth was recorded and who had an average of 10 measurements...

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Bibliographic Details
Published in:BMJ 1999-02, Vol.318 (7181), p.427-431
Main Authors: Eriksson, J G, Forsén, T, Tuomilehto, J, Winter, P D, Osmond, C, Barker, D J P
Format: Article
Language:English
Subjects:
Adolescent
Adults
Aged
Biological and medical sciences
Birth Weight
Body Height
Body Mass Index
Body Weight
Cardiology. Vascular system
Cardiovascular disease
Cell growth
Child
Child Nutritional Physiological Phenomena
Childhood
Children & youth
Coronary artery disease
Coronary Disease - mortality
Coronary heart disease
Crowding
Female
Fetal Growth Retardation - mortality
Finland - epidemiology
Follow-Up Studies
Growth Disorders - mortality
Heart
Humans
Infant, Low Birth Weight
Infant, Newborn
Longitudinal Studies
Male
Mass
Medical sciences
Mortality
Mothers
Nutrition
Overweight
Physical growth
Pregnancy
Prenatal development
Proportional Hazards Models
Risk Factors
Social Class
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Summary:Abstract Objective: To examine whether catch-up growth during childhood modifies the increased risk of death from coronary heart disease that is associated with reduced intrauterine growth. Design: Follow up study of men whose body size at birth was recorded and who had an average of 10 measurements taken of their height and weight through childhood. Setting: Helsinki, Finland. Subjects: 3641 men who were born in Helsinki University Central Hospital during 1924-33 and who went to school in Helsinki. Main outcome measures: Hazard ratios for death from coronary heart disease. Results: Death from coronary heart disease was associated with low birth weight and, more strongly, with a low ponderal index at birth. Men who died from coronary heart disease had an above average body mass index at all ages from 7 to 15 years. In a simultaneous regression the hazard ratio for death from the disease increased by 14% (95% confidence interval 8% to 19%; P
ISSN:0959-8138
0959-8146
1468-5833
1756-1833
DOI:10.1136/bmj.318.7181.427