Micronucleus analysis in patients with colorectal adenocarcinoma and colorectal polyps

To determine, by counting micronucleus (MN) frequencies, whether chromosomal or DNA damage have an effect on the pathogenesis of early colorectal adenocarcinoma (CRC). We analyzed MN frequencies in 21 patients with CRC, 24 patients with colon polyps [10 neoplastic polyps (NP) and 14 non-neoplastic p...

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Published in:World journal of gastroenterology : WJG 2008-11, Vol.14 (44), p.6835-6839
Main Authors: Karaman, Ali, Binici, Doğan Nasir, Kabalar, Mehmet Eşref, Calikuşu, Züleyha
Format: Article
Language:English
Subjects:
Adenocarcinoma - genetics
Adenocarcinoma - pathology
Aged
Case-Control Studies
Cell Transformation, Neoplastic - genetics
Cells, Cultured
Colonic Polyps - genetics
Colonic Polyps - pathology
Colonoscopy
Colorectal Neoplasms - genetics
Colorectal Neoplasms - pathology
Female
Gene Expression Regulation, Neoplastic
Genomic Instability
Humans
Male
Micronuclei, Chromosome-Defective
Micronucleus Tests
Middle Aged
Precancerous Conditions - genetics
Precancerous Conditions - pathology
Rapid Communication
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Summary:To determine, by counting micronucleus (MN) frequencies, whether chromosomal or DNA damage have an effect on the pathogenesis of early colorectal adenocarcinoma (CRC). We analyzed MN frequencies in 21 patients with CRC, 24 patients with colon polyps [10 neoplastic polyps (NP) and 14 non-neoplastic polyps (NNP)] and 20 normal controls. MN frequency was significantly increased in CRC patients and in NP patients compared with controls (3.72 +/- 1.34, 3.58 +/- 1.21 vs 1.97 +/- 0.81, P < 0.001). However, there was no difference in the MN frequency between CRC patients and NP patients (P > 0.05). Similarly, there was no difference in the MN frequency between NNP patients (2.06 +/- 0.85) and controls (P > 0.05). Our results suggest increased chromosome/DNA instabilities may be associated with the pathogenesis of early CRC.
ISSN:1007-9327
DOI:10.3748/wjg.14.6835