Diabetes mellitus as a risk factor for gastrointestinal cancer among American veterans

AIM： To assess the risk of biliary and pancreatic cancers in a large cohort of patients with type 2 diabetes mellitus （DM）. METHODS： Eligibility for this study included patients with type 2 DM （ICD-9 code 250.0） who were dis- charged from Department of Veteran Affairs hospitals between 1990 and 2000...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2009-11, Vol.15 (42), p.5274-5278
Main Authors: Jamal, M Mazen, Yoon, Eugene J, Vega, Kenneth J, Hashemzadeh, Mehrtash, Chang, Kenneth J
Format: Article
Language:English
Subjects:
2型糖尿病
Aged
Biliary Tract Neoplasms - epidemiology
Biliary Tract Neoplasms - etiology
Brief
Case-Control Studies
Cohort Studies
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - epidemiology
Female
Humans
Logistic Models
logistic回归
Male
Middle Aged
Pancreatic Neoplasms - epidemiology
Pancreatic Neoplasms - etiology
Risk Factors
United States - epidemiology
United States Department of Veterans Affairs
Veterans
危险因素
恶性肿瘤
消化道
退伍军人
风险因素
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Summary:AIM： To assess the risk of biliary and pancreatic cancers in a large cohort of patients with type 2 diabetes mellitus （DM）. METHODS： Eligibility for this study included patients with type 2 DM （ICD-9 code 250.0） who were dis- charged from Department of Veteran Affairs hospitals between 1990 and 2000. Non-matched control patients without DM were selected from the same patient treatment files during the same period. Demographic information included age, sex and race. Secondary diagnoses included known risk factors based on their ICD-9 codes. By multivariate logistic regression, the occurrence of biliary and pancreatic cancer was compared between case subjects with DM and controls without DM. RESULTS： A total of 1172496 case and control subjects were analyzed. The mean age for study and control subjects was 65.8 ＋ 11.3 and 64.8 ＋ 12.6 years, respectively. The frequency of pancreatic cancer in subjects with DM was increased （0.9%） in comparison to control subjects （0.3%） with an OR of 3.22 （95% CI： 3.03-3.42）. The incidence of gallbladder and extrahepatic biliary cancers was increased by twofold in diabetic patients when compared to controls. The OR and 95% CI were 2.20 （1.56-3.00） and 2.10 （1.61-2.53）, respectively. CONCLUSION： Our study demonstrated that patients with DM have a threefold increased risk for developing pancreatic cancer and a twofold risk for developing biliary cancer,
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.15.5274